| Accession | ARO:3003905 |
| Synonym(s) | aadD2 |
| CARD Short Name | ANT(4')-Ib |
| Definition | Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. |
| AMR Gene Family | ANT(4') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Bacillus subtilisg, Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Klebsiella quasipneumoniaep, Staphylococcus arlettaep, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+p, Staphylococcus schleiferig, Staphylococcus warnerip, Streptococcus suiswgs |
| Resistomes with Sequence Variants | Bacillus subtilisg+wgs, Bacillus thuringiensisp+wgs, Bacillus velezensiswgs, Enterobacter hormaecheiwgs, Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Escherichia coliwgs, Klebsiella quasipneumoniaep, Proteus mirabiliswgs, Providencia alcalifacienswgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Staphylococcus arlettaep+wgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+p+wgs, Staphylococcus hominisp+wgs, Staphylococcus pasteuriwgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus schleiferig, Staphylococcus warnerip+wgs, Stenotrophomonas maltophiliawgs, Streptococcus suiswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + nucleotidylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside nucleotidyltransferase (ANT) + aminoglycoside antibiotic [Drug Class] + ANT(4') [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic isepamicin [Antibiotic] + ANT(4')-I |
| Publications | McDougal LK, et al. 2010. Antimicrob. Agents Chemother. 54(9):3804-11 Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. (PMID 20585117) |
Prevalence of ANT(4')-Ib among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus subtilis | 2.26% | 0% | 0.65% | 0% |
| Bacillus thuringiensis | 0% | 0.2% | 0.48% | 0% |
| Bacillus velezensis | 0% | 0% | 0.92% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.05% | 0% |
| Enterococcus faecalis | 0% | 1.66% | 0.87% | 0% |
| Enterococcus faecium | 0% | 0% | 0.27% | 0% |
| Escherichia coli | 0% | 0% | 0.04% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.27% | 0% | 0% |
| Proteus mirabilis | 0% | 0% | 0.27% | 0% |
| Providencia alcalifaciens | 0% | 0% | 3.7% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.06% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Staphylococcus arlettae | 0% | 11.11% | 2.5% | 0% |
| Staphylococcus aureus | 8.26% | 5.79% | 10.57% | 0% |
| Staphylococcus capitis | 42.86% | 0% | 13.07% | 0% |
| Staphylococcus epidermidis | 2.73% | 2.33% | 19.87% | 0% |
| Staphylococcus haemolyticus | 12.5% | 2.33% | 11.21% | 0% |
| Staphylococcus hominis | 0% | 2.17% | 13.85% | 0% |
| Staphylococcus pasteuri | 0% | 0% | 4.17% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.53% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 0.75% | 0% |
| Staphylococcus schleiferi | 28.57% | 0% | 0% | 0% |
| Staphylococcus warneri | 0% | 7.69% | 5.26% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.52% | 0% |
| Streptococcus suis | 0% | 0% | 1.39% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450