amikacin [Antibiotic]

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Accession ARO:0000013
Synonym(s)AMK Arikace Lukadin mikacin Mikavir amikacine Amikacinum Kaminax Amikacina Amicacin Amikavet
DefinitionAmikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
79 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ AAC(6')-Iad targeted_by_antibiotic
+ AAC(6')-Iag confers_resistance_to_antibiotic
+ APH(2'') [AMR Gene Family] confers_resistance_to_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin confers_resistance_to_antibiotic
+ APH(3')-VI confers_resistance_to_antibiotic
+ AAC(6')-Ib' confers_resistance_to_antibiotic
+ APH(3')-VIb confers_resistance_to_antibiotic
+ Acinetobacter baumannii AbuO confers_resistance_to_antibiotic
+ AAC(6')-Im confers_resistance_to_antibiotic
+ AAC(3)-IIb confers_resistance_to_antibiotic
+ AAC(2')-Ia confers_resistance_to_antibiotic
+ AAC(2')-Ib confers_resistance_to_antibiotic
+ AAC(2')-Ic confers_resistance_to_antibiotic
+ AAC(2')-Id confers_resistance_to_antibiotic
+ AAC(2')-Ie confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ APH(3')-VIa confers_resistance_to_antibiotic
+ aphA15 confers_resistance_to_antibiotic
+ AAC(6')-Ian confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr3 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr4 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr5 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr6 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr7 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr8 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr9 confers_resistance_to_antibiotic
+ AAC(6')-Ib11 confers_resistance_to_antibiotic
+ AAC(6')-Ib3 confers_resistance_to_antibiotic
+ AAC(6')-If confers_resistance_to_antibiotic
+ AAC(6')-Ig confers_resistance_to_antibiotic
+ AAC(6')-Ih confers_resistance_to_antibiotic
+ AAC(6')-Ij confers_resistance_to_antibiotic
+ AAC(6')-Ik confers_resistance_to_antibiotic
+ AAC(6')-Il confers_resistance_to_antibiotic
+ AAC(6')-Iq confers_resistance_to_antibiotic
+ AAC(6')-Ir confers_resistance_to_antibiotic
+ AAC(6')-Is confers_resistance_to_antibiotic
+ AAC(6')-It confers_resistance_to_antibiotic
+ AAC(6')-Iu confers_resistance_to_antibiotic
+ AAC(6')-Iv confers_resistance_to_antibiotic
+ AAC(6')-Iw confers_resistance_to_antibiotic
+ AAC(6')-Ix confers_resistance_to_antibiotic
+ AAC(6')-29b confers_resistance_to_antibiotic
+ AAC(6')-29a confers_resistance_to_antibiotic
+ AAC(6')-31 confers_resistance_to_antibiotic
+ AAC(6')-32 confers_resistance_to_antibiotic
+ AAC(6')-Ia confers_resistance_to_antibiotic
+ AAC(6')-Iaa confers_resistance_to_antibiotic
+ AAC(6')-Iae confers_resistance_to_antibiotic
+ AAC(6')-Iaf confers_resistance_to_antibiotic
+ AAC(6')-Iai confers_resistance_to_antibiotic
+ PvrR confers_resistance_to_antibiotic
+ npmA confers_resistance_to_antibiotic
+ rmtD confers_resistance_to_antibiotic
+ rmtD2 confers_resistance_to_antibiotic
+ rmtE confers_resistance_to_antibiotic
+ rmtE2 confers_resistance_to_antibiotic
+ rmtG confers_resistance_to_antibiotic
+ rmtH confers_resistance_to_antibiotic
+ ANT(4')-IIa confers_resistance_to_antibiotic
+ ANT(4')-IIb confers_resistance_to_antibiotic
+ ANT(4')-Ib confers_resistance_to_antibiotic
+ APH(2'')-IIIa confers_resistance_to_antibiotic
+ APH(2'')-IVa confers_resistance_to_antibiotic
+ APH(2'')-Ie confers_resistance_to_antibiotic
+ APH(2'')-Ig confers_resistance_to_antibiotic
+ APH(3')-VIIIa confers_resistance_to_antibiotic
+ APH(3')-VIIIb confers_resistance_to_antibiotic
+ APH(3')-XV confers_resistance_to_antibiotic
+ AAC(6')-Iap confers_resistance_to_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)