| Accession | ARO:3000861 |
| CARD Short Name | rmtC |
| Definition | RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA. |
| AMR Gene Family | 16S rRNA methyltransferase (G1405) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Aeromonas veroniiwgs, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Enterobacter asburiaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Vibrio vulnificuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas veroniiwgs, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Enterobacter asburiaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Vibrio vulnificuswgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic molecule + ribosomal alteration conferring antibiotic resistance + antibiotic target modifying enzyme + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + rRNA methyltransferase conferring antibiotic resistance + gentamicin [Antibiotic] + 16S ribosomal RNA methyltransferase |
| Parent Term(s) | 12 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic gentamicin C [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic isepamicin [Antibiotic] + confers_resistance_to_antibiotic G418 [Antibiotic] + confers_resistance_to_antibiotic arbekacin [Antibiotic] + confers_resistance_to_antibiotic gentamicin B [Antibiotic] + 16S rRNA methyltransferase (G1405) [AMR Gene Family] |
| Publications | Wachino J, et al. 2005. Antimicrob Agents Chemother 50(1): 178-184. Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides. (PMID 16377684) Zarubica T, et al. 2011. RNA 17(2): 346-355. The aminoglycoside resistance methyltransferases from the ArmA/Rmt family operate late in the 30S ribosomal biogenesis pathway. (PMID 21177880) Hopkins KL, et al. 2010. Emerg Infect Dis 16(4): 712-715. 16S rRNA methyltransferase RmtC in Salmonella enterica serovar Virchow. (PMID 20350396) Rahman M, et al. 2015. Emerging Infect. Dis. 21(11):2059-62 RmtC and RmtF 16S rRNA Methyltransferase in NDM-1-Producing Pseudomonas aeruginosa. (PMID 26488937) |
Prevalence of rmtC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Aeromonas veronii | 0% | 0% | 0.56% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% |
| Citrobacter freundii | 0% | 0% | 0.58% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.19% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.32% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.52% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.72% | 0% |
| Escherichia coli | 0% | 0.08% | 0.1% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.27% | 0% |
| Klebsiella pneumoniae | 0% | 0.18% | 0.45% | 0% |
| Providencia rettgeri | 0% | 0% | 1.91% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.01% | 0% |
| Serratia marcescens | 0% | 0.65% | 0.66% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500