arbekacin [Antibiotic]

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Accession ARO:3000654
Synonym(s)habekacin haberacin
DefinitionA synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
15 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ AAC(6') [AMR Gene Family] confers_resistance_to_antibiotic
+ APH(2'') [AMR Gene Family] confers_resistance_to_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ AAC(6')-Iag confers_resistance_to_antibiotic
+ AAC(2')-Ia confers_resistance_to_antibiotic
+ AAC(2')-Ib confers_resistance_to_antibiotic
+ AAC(2')-Ic confers_resistance_to_antibiotic
+ AAC(2')-Id confers_resistance_to_antibiotic
+ AAC(2')-Ie confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic

Akins RL and Rybak MJ. 2000. Antimicrob Agents Chemother 44(7): 1925-1929. In vitro activities of daptomycin, arbekacin, vancomycin, and gentamicin alone and/or in combination against glycopeptide intermediate-resistant Staphylococcus aureus in an infection model. (PMID 10858356)

Hamilton-Miller JM and Shah S. 1995. J Antimicrob Chemother 35(6): 865-868. Activity of the semi-synthetic kanamycin B derivative, arbekacin against methicillin-resistant Staphylococcus aureus. (PMID 7559197)