kanamycin A [Antibiotic]

Download Sequences


Accession ARO:0000049
Synonym(s)Aspidium kanamycin Kanamycin sulfate Kanamycine Aminodeoxykanamycin Kanamicina Kantrex Kanamycinum
DefinitionKanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
40 ontology terms | Show
+ ANT(4') [AMR Gene Family] confers_resistance_to_antibiotic
+ aphA15 confers_resistance_to_antibiotic
+ AAC(6') [AMR Gene Family] confers_resistance_to_antibiotic
+ APH(2'') [AMR Gene Family] confers_resistance_to_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A confers_resistance_to_antibiotic
+ Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A confers_resistance_to_antibiotic
+ AAC(3)-Ib/AAC(6')-Ib'' confers_resistance_to_antibiotic
+ APH(3')-VIb confers_resistance_to_antibiotic
+ APH(3')-Ib confers_resistance_to_antibiotic
+ AAC(6')-Iag confers_resistance_to_antibiotic
+ aacA43 confers_resistance_to_antibiotic
+ AAC(3)-IIc confers_resistance_to_antibiotic
+ AAC(3)-IIIb confers_resistance_to_antibiotic
+ AAC(3)-Xa confers_resistance_to_antibiotic
+ APH(3')-Ia confers_resistance_to_antibiotic
+ APH(3')-IIIa confers_resistance_to_antibiotic
+ kamB confers_resistance_to_antibiotic
+ Escherichia coli mipA confers_resistance_to_antibiotic
+ ANT(2'')-Ia confers_resistance_to_antibiotic
+ APH(3')-IIb confers_resistance_to_antibiotic
+ APH(3')-IIc confers_resistance_to_antibiotic
+ APH(3')-IVa confers_resistance_to_antibiotic
+ APH(3')-VIa confers_resistance_to_antibiotic
+ APH(3')-VIIa confers_resistance_to_antibiotic
+ APH(3')-VI confers_resistance_to_antibiotic
+ APH(2'')-If confers_resistance_to_antibiotic
+ Staphylococcys aureus LmrS confers_resistance_to_antibiotic
+ kdpDE [AMR Gene Family] confers_resistance_to_antibiotic
+ AAC(6')-Im confers_resistance_to_antibiotic
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)