| Accession | ARO:3005115 |
| CARD Short Name | AAC(6')-Ib-cr5 |
| Definition | A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. |
| AMR Gene Family | AAC(6'), AAC(6')-Ib-cr |
| Drug Class | aminoglycoside antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Enterobacter asburiaewgs, Enterobacter chengduensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericawgs, Serratia marcescenswgs, Shigella boydiiwgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Enterobacter asburiaewgs, Enterobacter chengduensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericawgs, Serratia marcescenswgs, Shigella boydiiwgs, Shigella sonneiwgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside modifying enzyme + aminoglycoside antibiotic [Drug Class] + aminoglycoside acetyltransferase (AAC) + AAC(6') [AMR Gene Family] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + AAC(6')-Ib-cr [AMR Gene Family] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] |
| Publications | Lebreton F, et al. 2021. JAC Antimicrob Resist 3(4):dlab179 A panel of diverse Pseudomonas aeruginosa clinical isolates for research and development. (PMID 34909689) |
Prevalence of AAC(6')-Ib-cr5 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0% | 0.77% | 0% |
| Citrobacter portucalensis | 0% | 0% | 2.7% | 0% |
| Citrobacter werkmanii | 0% | 0% | 10.26% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.19% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 0% | 0% | 5.43% | 0% |
| Enterobacter hormaechei | 0% | 0% | 3.71% | 0% |
| Enterobacter kobei | 0% | 0% | 0.87% | 0% |
| Escherichia coli | 0% | 0.01% | 1.51% | 0% |
| Klebsiella aerogenes | 0% | 0% | 1.69% | 0% |
| Klebsiella michiganensis | 0% | 0% | 1.06% | 0% |
| Klebsiella oxytoca | 0% | 0% | 1.68% | 0% |
| Klebsiella pneumoniae | 0% | 0.16% | 5.17% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 6.05% | 0% |
| Morganella morganii | 0% | 0% | 1.84% | 0% |
| Proteus mirabilis | 0% | 0% | 0.99% | 0% |
| Providencia rettgeri | 0% | 0% | 2.55% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Raoultella planticola | 0% | 0% | 2.56% | 0% |
| Salmonella enterica | 0% | 0% | 0.03% | 0% |
| Serratia marcescens | 0% | 0% | 1.97% | 0% |
| Shigella boydii | 0% | 0% | 2.22% | 0% |
| Shigella sonnei | 0% | 0% | 0.51% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300