| Accession | ARO:3002580 |
| CARD Short Name | AAC(6')-Ib9 |
| Definition | AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiip+wgs, Acinetobacter towneriwgs, Acinetobacter wuhouensiswgs, Aeromonas caviaeg+p+wgs+gi, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisg+wgs+gi, Burkholderia cenocepaciawgs, Burkholderia vietnamiensiswgs, Citrobacter freundiip+wgs, Citrobacter portucalensisp+wgs, Comamonas testosteroniwgs+gi, Delftia tsuruhatensisgi, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Klebsiella aerogenesp+wgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensiswgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiiwgs, Proteus mirabiliswgs, Proteus vulgariswgs, Providencia rettgeriwgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas monteiliip+wgs, Pseudomonas putidag+p+wgs, Pseudomonas stutzerig+p+wgs, Raoultella planticolap, Salmonella entericap+wgs, Serratia marcescensg+p+wgs, Shigella sonneiwgs, Sphingobium yanoikuyaep+wgs, Stenotrophomonas maltophiliawgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6')-I |
| Publications | Mugnier P, et al. 1998. Antimicrob Agents Chemother 42(12): 3113-3116. Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro. (PMID 9835500) |
Prevalence of AAC(6')-Ib9 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 21.59% | 0.62% | 11.38% | 13.21% |
| Acinetobacter haemolyticus | 0% | 2.44% | 0% | 0% |
| Acinetobacter johnsonii | 0% | 2.78% | 9.09% | 0% |
| Acinetobacter junii | 0% | 33.33% | 2.99% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 1.72% | 0% |
| Acinetobacter pittii | 0% | 0.99% | 0.57% | 0% |
| Acinetobacter towneri | 0% | 0% | 3.85% | 0% |
| Acinetobacter wuhouensis | 0% | 0% | 50% | 0% |
| Aeromonas caviae | 6.82% | 2.6% | 2.69% | 33.33% |
| Aeromonas hydrophila | 9.23% | 1.3% | 3.23% | 0% |
| Aeromonas veronii | 1.82% | 3.08% | 1.69% | 0% |
| Alcaligenes faecalis | 10% | 0% | 2.94% | 33.33% |
| Burkholderia cenocepacia | 0% | 0% | 0.22% | 0% |
| Burkholderia vietnamiensis | 0% | 0% | 1.72% | 0% |
| Citrobacter freundii | 0% | 2.77% | 5.61% | 0% |
| Citrobacter portucalensis | 0% | 5.88% | 7.21% | 0% |
| Comamonas testosteroni | 0% | 0% | 7.14% | 100% |
| Delftia tsuruhatensis | 0% | 0% | 0% | 100% |
| Enterobacter asburiae | 0% | 0.28% | 3.16% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 1.12% | 3.83% | 0% |
| Enterobacter hormaechei | 0% | 2.19% | 6.13% | 0% |
| Enterobacter kobei | 0% | 1.38% | 3.49% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 1.8% | 0% |
| Escherichia coli | 0.12% | 0.11% | 0.28% | 0.13% |
| Klebsiella aerogenes | 0% | 1.09% | 1.41% | 0% |
| Klebsiella michiganensis | 3.23% | 0.57% | 4.26% | 0% |
| Klebsiella oxytoca | 0% | 2.74% | 0.84% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.47% | 2.49% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0.79% | 0% |
| Laribacter hongkongensis | 0% | 0% | 2.08% | 0% |
| Leclercia adecarboxylata | 7.14% | 4.76% | 2.33% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Proteus mirabilis | 0% | 0% | 0.33% | 0% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Pseudomonas aeruginosa | 0.77% | 4.09% | 2.85% | 1.39% |
| Pseudomonas monteilii | 0% | 14.29% | 4.76% | 0% |
| Pseudomonas putida | 1.41% | 8% | 5.88% | 0% |
| Pseudomonas stutzeri | 3.57% | 9.09% | 0.76% | 0% |
| Raoultella planticola | 0% | 4.65% | 0% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.12% | 0% |
| Serratia marcescens | 1.52% | 1.29% | 3.15% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Sphingobium yanoikuyae | 0% | 4% | 5.88% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.74% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275