| Accession | ARO:3002579 |
| CARD Short Name | AAC(6')-Ib8 |
| Definition | AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter portucalensiswgs, Enterobacter asburiaep+wgs, Enterobacter hormaecheiwgs, Klebsiella huaxiensisp |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap, Aeromonas veroniip, Citrobacter freundiip+wgs, Citrobacter portucalensisp+wgs, Enterobacter asburiaep+wgs, Enterobacter cloacaeg, Enterobacter hormaecheig+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip+wgs, Klebsiella huaxiensisp, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabiliswgs, Providencia rettgerig+wgs, Providencia stuartiip, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs, Salmonella entericawgs, Serratia marcescenswgs, Vibrio parahaemolyticuswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6')-I |
| Publications | Casin I, et al. 1998. Antimicrob Agents Chemother 42(2): 209-215. Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii. (PMID 9527761) |
Prevalence of AAC(6')-Ib8 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Aeromonas caviae | 0% | 9.09% | 29.03% | 0% |
| Aeromonas hydrophila | 0% | 3.9% | 0% | 0% |
| Aeromonas veronii | 0% | 3.08% | 0% | 0% |
| Citrobacter freundii | 0% | 0.31% | 0.39% | 0% |
| Citrobacter portucalensis | 0% | 5.88% | 1.8% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 1.19% | 0% |
| Enterobacter cloacae | 1.79% | 0% | 0% | 0% |
| Enterobacter hormaechei | 0.36% | 0% | 2.29% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0.72% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Klebsiella huaxiensis | 0% | 7.69% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.06% | 0.11% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.06% | 0.26% | 0% |
| Proteus mirabilis | 0% | 0% | 0.5% | 0% |
| Providencia rettgeri | 5.88% | 0% | 0.64% | 0% |
| Providencia stuartii | 0% | 2.27% | 0% | 0% |
| Pseudomonas aeruginosa | 0.46% | 0.29% | 0.57% | 0% |
| Pseudomonas putida | 0% | 0% | 1.07% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Serratia marcescens | 0% | 0% | 0.26% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.05% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275