AAC(6')-Ib-cr3

Accession ARO:3005112
CARD Short NameAAC(6')-Ib-cr3
DefinitionA fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics.
AMR Gene FamilyAAC(6')-Ib-cr
Drug Classfluoroquinolone antibiotic, aminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Aeromonas caviaewgs, Citrobacter freundiiwgs, Citrobacter portucalensisg, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia coliwgs, Escherichia fergusoniip, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiip+wgs, Proteus mirabilisg+wgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericag+wgs, Serratia marcescenswgs, Vibrio alginolyticuswgs, Vibrio parahaemolyticuswgs
Classification10 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6')-Ib-cr [AMR Gene Family]
Publications

Quiroga MP, et al. 2015. Antimicrob Agents Chemother 59(5):2893-7 Characterization of Tn6238 with a new allele of aac(6')-Ib-cr. (PMID 25691640)

Resistomes

Prevalence of AAC(6')-Ib-cr3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.05%0%
Aeromonas caviae0%0%6.9%0%
Citrobacter freundii0%0%1.43%0%
Citrobacter portucalensis4%0%0%0%
Citrobacter werkmanii0%0%2.56%0%
Citrobacter youngae0%0%6.25%0%
Enterobacter asburiae0%0.91%1.33%0%
Enterobacter cloacae0%0%1.44%0%
Enterobacter hormaechei0%0%1.01%0%
Enterobacter kobei0%0%0.52%0%
Enterobacter roggenkampii0%0%0.81%0%
Escherichia coli0%0%0.15%0%
Escherichia fergusonii0%0.38%0%0%
Klebsiella aerogenes0%0%0.31%0%
Klebsiella michiganensis0%0%0.6%0%
Klebsiella pneumoniae0.07%0.07%2.29%0%
Klebsiella quasipneumoniae0%0%0.16%0%
Morganella morganii0%8.11%0.69%0%
Proteus mirabilis1.1%0%0.53%0%
Providencia rettgeri0%0%0.74%0%
Pseudomonas aeruginosa0%0%0.03%0%
Raoultella planticola0%0%2.78%0%
Salmonella enterica0.07%0%0.02%0%
Serratia marcescens0%0%0.41%0%
Vibrio alginolyticus0%0%0.67%0%
Vibrio parahaemolyticus0%0%0.06%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 275


>gb|ADY02579.1|+|AAC(6')-Ib-cr3 [Aeromonas media]
MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYA
QSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYG
PAVVMGQTRQAFERTRSDA


>gb|HQ170516.1|+|427-1026|AAC(6')-Ib-cr3 [Aeromonas media]
ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAG
CATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGAC
GTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCC
CAGTCGTACGTTGCTCTTGGAAGCGGGGACGGAAGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAAT
GCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAA
ACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAAAGGCAAGGTACCGTAACCACCCCATATGGT
CCAGCCGTGGTAATGGGTCAAACACGCCAAGCATTCGAGCGAACACGCAGTGATGCCTAA