| Accession | ARO:3005112 |
| CARD Short Name | AAC(6')-Ib-cr3 |
| Definition | A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. |
| AMR Gene Family | AAC(6'), AAC(6')-Ib-cr |
| Drug Class | aminoglycoside antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaewgs, Citrobacter freundiiwgs, Citrobacter portucalensisg, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia coliwgs, Escherichia fergusoniip, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiip+wgs, Proteus mirabilisg+wgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericag+wgs, Serratia marcescenswgs, Vibrio alginolyticuswgs, Vibrio parahaemolyticuswgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + antibiotic molecule + acylation of antibiotic conferring resistance + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + AAC(6')-Ib-cr [AMR Gene Family] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] |
| Publications | Quiroga MP, et al. 2015. Antimicrob Agents Chemother 59(5):2893-7 Characterization of Tn6238 with a new allele of aac(6')-Ib-cr. (PMID 25691640) |
Prevalence of AAC(6')-Ib-cr3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.05% | 0% |
| Aeromonas caviae | 0% | 0% | 6.9% | 0% |
| Citrobacter freundii | 0% | 0% | 1.43% | 0% |
| Citrobacter portucalensis | 4% | 0% | 0% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Enterobacter asburiae | 0% | 0.91% | 1.33% | 0% |
| Enterobacter cloacae | 0% | 0% | 1.44% | 0% |
| Enterobacter hormaechei | 0% | 0% | 1.01% | 0% |
| Enterobacter kobei | 0% | 0% | 0.52% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.81% | 0% |
| Escherichia coli | 0% | 0% | 0.15% | 0% |
| Escherichia fergusonii | 0% | 0.38% | 0% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.31% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.6% | 0% |
| Klebsiella pneumoniae | 0.07% | 0.07% | 2.29% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.16% | 0% |
| Morganella morganii | 0% | 8.11% | 0.69% | 0% |
| Proteus mirabilis | 1.1% | 0% | 0.53% | 0% |
| Providencia rettgeri | 0% | 0% | 0.74% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.03% | 0% |
| Raoultella planticola | 0% | 0% | 2.78% | 0% |
| Salmonella enterica | 0.07% | 0% | 0.02% | 0% |
| Serratia marcescens | 0% | 0% | 0.41% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.67% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.06% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275