| Accession | ARO:3002577 |
| CARD Short Name | AAC(6')-Ib4 |
| Definition | AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp. |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+p+wgs, Acinetobacter defluviip, Acinetobacter lwoffiip, Acinetobacter pittiip+wgs, Alcaligenes faecaliswgs, Burkholderia cenocepaciawgs, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter asburiaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheig+p+wgs+gi, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Klebsiella aerogenesp, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep, Pseudomonas aeruginosap+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas stutzerip+wgs, Serratia marcescensp+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs, Acinetobacter defluviip, Acinetobacter lwoffiip, Acinetobacter pittiip+wgs, Alcaligenes faecaliswgs, Burkholderia cenocepaciawgs, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter asburiaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheig+p+wgs+gi, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Klebsiella aerogenesp, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep, Pseudomonas aeruginosap+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas putidap, Pseudomonas stutzerip+wgs, Serratia marcescensp+wgs, Stenotrophomonas maltophiliawgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(6') [AMR Gene Family] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6')-I |
| Publications | Toriya M, et al. 1992. Chem Pharm Bull (Tokyo) 40(9): 2473-2477. Nucleotide sequence of aminoglycoside 6'-N-acetyltransferase [AAC(6')] determinant from Serratia sp. 45. (PMID 1339319) |
Prevalence of AAC(6')-Ib4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0.05% | 0.03% | 0% | 0% |
| Acinetobacter defluvii | 0% | 12.5% | 0% | 0% | 0% |
| Acinetobacter lwoffii | 0% | 1.39% | 0% | 0% | 0% |
| Acinetobacter pittii | 0% | 0.49% | 0.57% | 0% | 0% |
| Alcaligenes faecalis | 0% | 0% | 11.76% | 0% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 4.39% | 0% | 0% |
| Citrobacter freundii | 0% | 0.62% | 2.71% | 0% | 0% |
| Citrobacter portucalensis | 0% | 0% | 2.7% | 0% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.58% | 0% | 0% |
| Enterobacter cloacae | 0% | 0% | 4.15% | 0% | 0% |
| Enterobacter hormaechei | 0.36% | 0.71% | 2.63% | 3.33% | 0% |
| Enterobacter kobei | 0% | 1.38% | 1.31% | 0% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.36% | 0% | 0% |
| Escherichia coli | 0% | 0.03% | 0.07% | 0% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 0% | 0% | 0% |
| Klebsiella michiganensis | 0% | 1.71% | 2.39% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0.42% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.12% | 0.15% | 0% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.64% | 0% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 2.63% | 1.92% | 4.17% | 0% |
| Pseudomonas monteilii | 0% | 0% | 9.52% | 0% | 0% |
| Pseudomonas putida | 0% | 4% | 0% | 0% | 0% |
| Pseudomonas stutzeri | 0% | 9.09% | 3.05% | 0% | 0% |
| Serratia marcescens | 0% | 1.29% | 4.85% | 0% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.15% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 275
| Curator | Description | Most Recent Edit |
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