kdpDE [AMR Gene Family]

Accession ARO:3004046
DefinitionkdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification6 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ determinant of aminoglycoside resistance
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
2 ontology terms | Show
+ kdpE part_of
+ kdpD part_of

Freeman ZN, et al. 2013. PLoS Pathog. 9(3):e1003201 The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. (PMID 23555240)