Accession | ARO:3004046 |
Definition | kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. |
Drug Class | aminoglycoside antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
Classification | 6 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + determinant of antibiotic resistance |
Parent Term(s) | 3 ontology terms | Show + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] |
Sub-Term(s) | 2 ontology terms | Show |
Publications | Freeman ZN, et al. 2013. PLoS Pathog. 9(3):e1003201 The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. (PMID 23555240) |