| Accession | ARO:3003841 |
| CARD Short Name | kdpE |
| Definition | kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. |
| AMR Gene Family | kdpDE |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Escherichia colig+p+wgs, Shigella boydiig+wgs, Shigella flexnerig+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Escherichia marmotaeg+wgs, Klebsiella pneumoniaewgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + kanamycin A [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + protein of two-component regulatory system modulating antibiotic efflux + part_of kdpDE [AMR Gene Family] |
| Publications | Hirakawa H, et al. 2003. J Bacteriol 185(6): 1851-1856. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. (PMID 12618449) Freeman ZN, et al. 2013. PLoS Pathog. 9(3):e1003201 The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. (PMID 23555240) |
Prevalence of kdpE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter amalonaticus | 100% | 0% | 89.09% | 0% |
| Citrobacter freundii | 100% | 0% | 50.29% | 0% |
| Citrobacter koseri | 93.75% | 0% | 48.65% | 0% |
| Citrobacter portucalensis | 96.3% | 0% | 61.26% | 0% |
| Citrobacter werkmanii | 100% | 0% | 61.54% | 0% |
| Citrobacter youngae | 100% | 0% | 100% | 0% |
| Escherichia albertii | 100% | 0% | 61.94% | 0% |
| Escherichia coli | 67.34% | 0.01% | 61.02% | 0% |
| Escherichia fergusonii | 98.36% | 0.36% | 48.91% | 0% |
| Escherichia marmotae | 100% | 0% | 70.83% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Salmonella bongori | 100% | 0% | 89.47% | 0% |
| Salmonella enterica | 95.52% | 0% | 80.54% | 0% |
| Shigella boydii | 100% | 0% | 94.44% | 0% |
| Shigella dysenteriae | 100% | 0% | 100% | 0% |
| Shigella flexneri | 65% | 0% | 14.13% | 0% |
| Shigella sonnei | 100% | 0% | 94.89% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400