kdpD

Accession ARO:3004047
CARD Short NamekdpD
DefinitionkdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE.
AMR Gene FamilykdpDE
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesStaphylococcus aureuswgs
Resistomes with Sequence VariantsStaphylococcus aureusg+p+wgs
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Freeman ZN, et al. 2013. PLoS Pathog. 9(3):e1003201 The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. (PMID 23555240)

Resistomes

Prevalence of kdpD among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Staphylococcus aureus98.6%0.04%55.26%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1500


>gb|CYF42523.1|-|kdpD [Staphylococcus aureus]
MSNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNIDIKIGYIEPHQRDETNALAEQLPKIATNFTKHGSHHFQYLDVDRII
KESPTIVLIDELAHTNISRDRHEKRYMDIEEILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDYFIMSADVLEVVDISPEQLIK
RLKAGKVYKKDRLDVAFSNFFTYTHLSELRTLTLRTVADLMSDKEKVRHNHKTSLKPHIAVAISGSIYNEAVIKEAFHIAQKEHAKFTAI
YIDVFEKNRQYKDSQKQVHQHLMLAKSLGAKVKVVYSQTVALGLDEWCKNQDVTKLIIGQHIRNKWRDFFNTPLIDHLMSFEHSYKIEIV
PIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMMGLWIYQLDKHESSTIILMIFLIGIILLSIWTRSYIIGFLAAIINVFVFNY
FFTEPRYTFEVYRFDYPITFIVSILTSILTSALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITVYV
INQSKVIKTIPLQNHIDNTTQQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIKGILAIDYQSSQVINPYDASILESMLNELSL
AVENVSLLKQTRESMLQAERQLTHSNFLRSISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQS
SNVQIKLQPYLVSELVEEIDMILERRHLKKRITVSSSVDLQFIHIDSKLILQALFNLIENAVKHTSTDTKINLSIRYASDEQIEFAVIDE
GPGISLEEQQKIFEPFYTGSNKYFKDNQKESMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDFNEGDI


>gb|FHDU01000010.1|-|53979-56636|kdpD [Staphylococcus aureus]
ATGTCAAACACTGAATCGCTAAACATAGGAAAAAAGCGTGGATCTTTAACAATTTACATCGGTTACAGTCCAGGTGTTGGTAAAACATTT
GAGATGCTTTCAAATGCCATTGAACTATTTCAAAGTAACATTGATATTAAAATAGGATATATTGAACCGCATCAACGTGATGAAACAAAT
GCATTAGCTGAACAATTACCTAAAATCGCAACCAATTTTACTAAACATGGTAGTCATCATTTTCAATATTTAGATGTCGACCGCATAATC
AAAGAATCGCCGACAATAGTACTTATCGATGAGTTAGCACATACGAACATTTCTAGAGATCGTCATGAGAAACGATATATGGATATTGAA
GAAATTTTAAATCATGGTATCGATGTTCATACTACTTTGAACATTCAACATATCGAAAGTTTAAGTAGTCAAATTGAACTGATGACCGGT
GTACATGTTAAAGAACGTGTACCCGACTATTTCATAATGAGCGCCGATGTATTAGAAGTCGTAGATATCTCACCTGAACAATTAATTAAG
CGCTTAAAAGCTGGCAAGGTATATAAAAAGGATAGGCTAGATGTAGCATTTAGTAATTTCTTTACGTATACCCACCTAAGCGAACTGCGT
ACATTGACGTTAAGAACAGTTGCCGACTTGATGAGTGATAAAGAAAAAGTCCGACACAATCATAAAACGTCACTCAAACCTCATATTGCT
GTGGCAATTAGTGGGAGCATTTATAATGAAGCAGTAATTAAAGAGGCATTCCATATTGCTCAAAAAGAACATGCAAAATTCACTGCTATT
TATATAGATGTATTCGAAAAGAACAGGCAATATAAAGATAGTCAAAAGCAAGTGCATCAACATCTCATGCTTGCAAAATCTTTAGGAGCA
AAAGTGAAAGTAGTTTATAGCCAAACCGTTGCATTAGGATTAGACGAATGGTGTAAAAATCAAGATGTAACCAAATTAATTATCGGACAA
CATATTAGAAATAAGTGGCGAGACTTTTTCAATACACCTTTAATTGACCATTTAATGTCCTTTGAACATAGCTATAAAATCGAAATCGTT
CCAATCAAACAAATACCTGTTGAATTGAAAATGAACAAATCACCCTATCGTCCTAAAGGCAAACGTTTCGCCATAGATATGTTAAAAATG
ATTTTGATTCAAATAATTTGTGTAATGATGGGACTGTGGATTTATCAACTTGATAAGCATGAGTCTAGTACGATTATTTTAATGATTTTT
CTCATCGGCATCATTTTATTATCCATTTGGACGCGGTCCTACATCATTGGCTTTTTAGCAGCAATTATTAACGTATTTGTTTTTAATTAT
TTTTTTACGGAACCTAGATATACATTTGAAGTATACCGCTTTGACTATCCTATTACATTTATCGTTAGCATTTTAACAAGTATTTTAACG
AGTGCTTTATTAAAACAAATTAAATTCCAATACTCCATTACTAAAAAGCAACTTTATCGTACAGATTTATTATTTCAATTTAATGATTCG
ATTAAACAAACTTATACAGTTGAAAACTTACTAATAAATGCTGGATACCAAATTAATCAATTATTGCAACAATCAATTACTGTATACGTT
ATCAATCAATCGAAAGTAATTAAAACAATACCATTGCAAAACCATATCGATAATACGACTCAACAGCATGAACAAGCATTAAGCTGGGTA
ATTAAAAATGAAAGACAAGCTGGTGCAACAACAGATACATTTCCAGGCATTAATAAATGGTTGATACCAATTGGCACATCTCCGATTAAA
GGCATTCTAGCCATTGATTACCAAAGTTCTCAAGTGATTAATCCATATGATGCATCAATATTAGAATCAATGTTAAATGAACTTTCTCTC
GCCGTTGAAAATGTGTCGTTACTTAAACAAACGAGAGAATCCATGTTACAGGCTGAACGTCAACTGACACATTCAAATTTTTTAAGATCA
ATTTCGCATGACATACGTACACCGTTAACAACAATTATGGGAAATTTAGATATTTTAGTATCACATAGTAAAGATATGTCTATCATAGAA
AAAGAACAATTACTTGTGCATAGTTTTCAAGAAAGTCAGTATTTATATCTATTAGTGACAAATATTTTATCATTAACAAAATTACAGTCA
TCAAATGTTCAGATAAAATTGCAACCTTATCTCGTTAGTGAATTAGTAGAAGAAATCGATATGATTCTAGAACGTCGCCATTTAAAAAAG
CGTATAACTGTATCATCCTCAGTAGATTTACAGTTTATACACATTGACAGTAAGTTGATTTTACAAGCTTTATTCAATTTGATTGAAAAT
GCAGTTAAACACACTTCTACTGACACCAAAATCAATTTATCTATTCGTTATGCTAGCGATGAACAAATCGAATTTGCCGTTATAGACGAA
GGACCTGGAATTAGTTTAGAAGAACAACAAAAGATATTCGAGCCTTTTTACACAGGATCAAATAAATATTTTAAAGATAACCAAAAAGAA
AGCATGGGACTAGGCTTATATTTAGTACAGACTATCCTACACAAACATCAATCAAACTTACAATATAAACCGAACCAACCACACGGCAGT
ATATTCTATTTCAATATAGATACAGACTTTAATGAAGGAGACATATAA