aacA43

Accession ARO:3004641
CARD Short NameaacA43
DefinitionaacA43 is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae.
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs
Classification9 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6') [AMR Gene Family]
Publications

Partridge SR, et al. 2011. Antimicrob. Agents Chemother. 55(6):2979-82 A novel gene cassette, aacA43, in a plasmid-borne class 1 integron. (PMID 21422220)

Resistomes

Prevalence of aacA43 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.03%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 330


>gb|AEA07977.1|+|aacA43 [Klebsiella pneumoniae]
MIYNIINIADSEKNKEDAARILYSAFRGKGKDAWPTLDSAREEIAECIASPNICLGITLDDRLVGWGGLRPMYETTWELHPLVIDPDYQG
NGLGRLLLSKIESTATTNRIIGIMLGTDDETLSTSLSMTDIDESNIFQEIKNIINIKNHPFEFYKKCGYIIVGIVPNANGYRKPDIWMWK
NLEKKSG


>gb|HQ247816.1|+|639-1202|aacA43 [Klebsiella pneumoniae]
ATGATTTATAACATAATTAACATTGCTGATTCTGAAAAGAACAAGGAAGACGCTGCACGAATTCTATATTCTGCATTTCGCGGAAAGGGA
AAAGATGCTTGGCCTACATTAGATTCAGCTCGTGAAGAAATAGCAGAGTGCATAGCAAGTCCTAATATTTGCTTGGGCATAACCTTAGAT
GATCGCTTAGTAGGGTGGGGCGGACTTCGTCCCATGTATGAAACCACATGGGAATTGCATCCCTTAGTAATAGATCCTGATTATCAAGGT
AATGGATTAGGAAGACTGCTCCTATCAAAGATTGAGAGCACTGCAACCACAAATAGAATAATTGGTATAATGCTTGGAACAGATGATGAG
ACATTGAGTACAAGTCTTTCAATGACTGATATAGATGAGTCTAATATTTTCCAAGAGATAAAAAATATAATTAATATAAAGAATCATCCA
TTTGAATTTTATAAAAAATGCGGGTACATCATTGTCGGTATAGTACCTAACGCAAATGGGTATAGAAAACCTGACATTTGGATGTGGAAG
AATCTAGAAAAGAAAAGTGGCTAA