aacA43

Accession ARO:3004641
DefinitionaacA43 is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae
AMR Gene FamilyAAC(6')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs
Classification19 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(6') [AMR Gene Family]
Publications

Partridge SR, et al. 2011. Antimicrob. Agents Chemother. 55(6):2979-82 A novel gene cassette, aacA43, in a plasmid-borne class 1 integron. (PMID 21422220)

Resistomes

Prevalence of aacA43 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0%0.05%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 330


>gb|AEA07977.1|+|aacA43 [Klebsiella pneumoniae]
MIYNIINIADSEKNKEDAARILYSAFRGKGKDAWPTLDSAREEIAECIASPNICLGITLDDRLVGWGGLRPMYETTWELHPLVIDPDYQG
NGLGRLLLSKIESTATTNRIIGIMLGTDDETLSTSLSMTDIDESNIFQEIKNIINIKNHPFEFYKKCGYIIVGIVPNANGYRKPDIWMWK
NLEKKSG


>gb|HQ247816.1|+|639-1202|aacA43 [Klebsiella pneumoniae]
ATGATTTATAACATAATTAACATTGCTGATTCTGAAAAGAACAAGGAAGACGCTGCACGAATTCTATATTCTGCATTTCGCGGAAAGGGA
AAAGATGCTTGGCCTACATTAGATTCAGCTCGTGAAGAAATAGCAGAGTGCATAGCAAGTCCTAATATTTGCTTGGGCATAACCTTAGAT
GATCGCTTAGTAGGGTGGGGCGGACTTCGTCCCATGTATGAAACCACATGGGAATTGCATCCCTTAGTAATAGATCCTGATTATCAAGGT
AATGGATTAGGAAGACTGCTCCTATCAAAGATTGAGAGCACTGCAACCACAAATAGAATAATTGGTATAATGCTTGGAACAGATGATGAG
ACATTGAGTACAAGTCTTTCAATGACTGATATAGATGAGTCTAATATTTTCCAAGAGATAAAAAATATAATTAATATAAAGAATCATCCA
TTTGAATTTTATAAAAAATGCGGGTACATCATTGTCGGTATAGTACCTAACGCAAATGGGTATAGAAAACCTGACATTTGGATGTGGAAG
AATCTAGAAAAGAAAAGTGGCTAA