| Accession | ARO:3004641 |
| Definition | aacA43 is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae |
| AMR Gene Family | AAC(6') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs |
| Classification | 19 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + aminoglycoside antibiotic [Drug Class] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance + arbekacin [Antibiotic] + aminoglycoside acetyltransferase (AAC) + tobramycin [Antibiotic] + sisomicin [Antibiotic] + kanamycin A [Antibiotic] + neomycin [Antibiotic] + isepamicin [Antibiotic] + netilmicin [Antibiotic] + amikacin [Antibiotic] + gentamicin B [Antibiotic] + dibekacin [Antibiotic] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + AAC(6') [AMR Gene Family] |
| Publications | Partridge SR, et al. 2011. Antimicrob. Agents Chemother. 55(6):2979-82 A novel gene cassette, aacA43, in a plasmid-borne class 1 integron. (PMID 21422220) |
Prevalence of aacA43 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.05% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 330