| Accession | ARO:3004677 |
| CARD Short Name | rmtD2 |
| Definition | The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. |
| AMR Gene Family | 16S rRNA methyltransferase (G1405) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Aeromonas hydrophilawgs, Citrobacter koseriwgs, Enterobacter hormaecheiwgs |
| Resistomes with Sequence Variants | Aeromonas hydrophilawgs, Citrobacter koseriwgs, Enterobacter hormaecheiwgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + ribosomal alteration conferring antibiotic resistance + antibiotic molecule + antibiotic target modifying enzyme + rRNA methyltransferase conferring antibiotic resistance + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + gentamicin [Antibiotic] + 16S ribosomal RNA methyltransferase |
| Parent Term(s) | 6 ontology terms | Show + 16S rRNA methyltransferase (G1405) [AMR Gene Family] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic gentamicin A [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] |
| Publications | Tijet N, et al. 2011. Antimicrob. Agents Chemother. 55(2):904-9 rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade. (PMID 21078935) |
Prevalence of rmtD2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas hydrophila | 0% | 0% | 0.81% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500