| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3004015 |
| Synonym(s) | Garamycin |
| Definition | Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death. |
| SMILES | CN[C@@H]1C(O)[C@@H](OC2[C@H](N)CC(N)[C@@H](O[C@H]3OC(CO)[C@@H](O)[C@H](O)C3NO)[C@@H]2O)OC[C@H]1O |
| PubChem | 12810388 |
| ChEBI | 28418 |
| CAS | 13291-74-2 |
| ChEMBL | CHEMBL7225 |
| Drug Class | aminoglycoside antibiotic |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + gentamicin [Antibiotic] |
| Sub-Term(s) | 19 ontology terms | Show + APH(2'')-If confers_resistance_to_antibiotic + AAC(3)-IVb confers_resistance_to_antibiotic + AAC(3)-IIIc confers_resistance_to_antibiotic + AAC(6')-30/AAC(6')-Ib' bifunctional protein confers_resistance_to_antibiotic + PvrR confers_resistance_to_antibiotic + npmA confers_resistance_to_antibiotic + rmtD confers_resistance_to_antibiotic + rmtD2 confers_resistance_to_antibiotic + rmtE confers_resistance_to_antibiotic + rmtE2 confers_resistance_to_antibiotic + rmtF confers_resistance_to_antibiotic + rmtG confers_resistance_to_antibiotic + rmtH confers_resistance_to_antibiotic + APH(2'')-IIIa confers_resistance_to_antibiotic + APH(2'')-IVa confers_resistance_to_antibiotic + APH(2'')-Ig confers_resistance_to_antibiotic + APH(2'')-Ie confers_resistance_to_antibiotic + ANT(3'')-II-AAC(6')-IId bifunctional protein confers_resistance_to_antibiotic + AAC(6')-Ie-APH(2'')-Ia bifunctional protein confers_resistance_to_antibiotic |
| Publications | Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623) Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173) |
| Curator | Description | Most Recent Edit |
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