AAC(3)-IVb

Accession ARO:3005061
Synonym(s)aacC10
CARD Short NameAAC(3)-IVb
DefinitionA novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin.
AMR Gene FamilyAAC(3)
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ AAC(3) [AMR Gene Family]
+ confers_resistance_to_antibiotic gentamicin A [Antibiotic]
Publications

Ruiz C, et al. 2019. mSphere 4(5): Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii. (PMID 31578249)

Resistomes

Prevalence of AAC(3)-IVb among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|QEQ43476.1|+|AAC(3)-IVb [Cupriavidus gilardii]
MVTQLRALGVPPGAVLLVHASFRSIRPVQGGPQGLIEALREAAGPAGTLVMPSWGDDDDAPFDPAATPAAADLGAVADAFWRLPDVVRSH
HPFAFAAAGPQAHRITADPLPLPPHIPASPVGRVHELDGQVLLLGVGHDANTTIHLAELMAGVPYGVPHHCTVLRDGKPARIDYLENDHC
CQRFDLVDGWLKEKGLQREGPVGNAGARLMRARDIVDVVRQQLARDPLVFLHPPQVGCEECDAARRSVSTK


>gb|MN366378.1|+|1-756|AAC(3)-IVb [Cupriavidus gilardii]
TTGGTGACCCAGTTGCGCGCGCTCGGCGTGCCACCCGGCGCCGTGCTGCTGGTCCACGCGTCGTTCCGCTCGATCAGGCCCGTGCAAGGG
GGCCCACAAGGATTGATCGAGGCGCTGCGGGAAGCGGCCGGCCCTGCCGGCACGCTGGTGATGCCGTCGTGGGGCGATGACGATGACGCG
CCCTTCGACCCGGCCGCCACGCCGGCAGCGGCGGACCTTGGCGCGGTCGCCGATGCCTTCTGGCGACTGCCCGACGTGGTTCGCAGCCAC
CACCCGTTTGCCTTCGCGGCGGCGGGACCGCAGGCGCATCGAATCACCGCGGATCCCTTGCCGTTGCCGCCCCATATTCCGGCCAGCCCG
GTCGGCCGCGTGCACGAGCTCGATGGACAGGTGCTGCTGCTTGGCGTGGGCCATGACGCCAACACCACGATCCATCTGGCCGAACTGATG
GCCGGCGTGCCTTACGGCGTGCCGCATCACTGCACGGTGCTGCGGGACGGCAAGCCGGCTCGCATCGACTATCTCGAAAACGACCACTGC
TGCCAGCGCTTCGATCTGGTGGACGGATGGCTCAAGGAAAAGGGCCTTCAGCGTGAAGGCCCAGTTGGCAATGCCGGCGCCCGCTTGATG
CGGGCGCGGGACATCGTCGATGTCGTGCGGCAGCAGTTGGCTCGCGATCCGCTCGTCTTCCTGCATCCGCCTCAGGTTGGCTGCGAGGAG
TGCGATGCCGCGCGGCGGTCGGTCAGCACCAAGTAG