| Accession | ARO:3002669 |
| CARD Short Name | APH(2'')-Ig |
| Definition | APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. |
| AMR Gene Family | APH(2'') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Campylobacter colip+wgs, Campylobacter jejunip+wgs |
| Resistomes with Sequence Variants | Campylobacter colip+wgs, Campylobacter jejunip+wgs, Ruthenibacterium lactatiformanswgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + antibiotic mixture + aminoglycoside antibiotic [Drug Class] + phosphorylation of antibiotic conferring resistance + aminoglycoside phosphotransferase (APH) + gentamicin [Antibiotic] |
| Parent Term(s) | 5 ontology terms | Show + APH(2'') [AMR Gene Family] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic gentamicin A [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] |
| Publications | Chen Y, et al. 2013. Antimicrob Agents Chemother 57(11): 5398-5405. Whole-genome sequencing of gentamicin-resistant Campylobacter coli isolated from U.S. retail meats reveals novel plasmid-mediated aminoglycoside resistance genes. (PMID 23959310) |
Prevalence of APH(2'')-Ig among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter coli | 0% | 3.64% | 3.17% | 0% |
| Campylobacter jejuni | 0% | 1.98% | 0.05% | 0% |
| Ruthenibacterium lactatiformans | 0% | 0% | 3.33% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550