aminoglycoside phosphotransferase (APH)

Accession ARO:3000114
Synonym(s)aminoglycoside kinase
DefinitionKinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor.
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
7 ontology terms | Show
+ APH(3') [AMR Gene Family]
+ APH(3'') [AMR Gene Family]
+ APH(2'') [AMR Gene Family]
+ APH(6) [AMR Gene Family]
+ APH(9) [AMR Gene Family]
+ APH(7'') [AMR Gene Family]
+ APH(4) [AMR Gene Family]

Wright GD and Thompson PR. 1999. Front Biosci 4: D9-D21. Aminoglycoside phosphotransferases: proteins, structure, and mechanism. (PMID 9872733)

Ramirez MS and Tolmasky ME. 2010. Drug Resist Updat 13(6): 151-171. Aminoglycoside modifying enzymes. (PMID 20833577)