APH(4) [AMR Gene Family]

Accession ARO:3000155
DefinitionPhosphorylation of hygromycin on the hydroxyl group at position 4
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_antibiotic hygromycin B [Antibiotic]
2 ontology terms | Show

Stogios PJ, et al. 2011. J Biol Chem 286(3): 1966-1975. Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme. (PMID 21084294)