APH(4) [AMR Gene Family]

Accession ARO:3000155
DefinitionA category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
1 ontology terms | Show

Stogios PJ, et al. 2011. J Biol Chem 286(3): 1966-1975. Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme. (PMID 21084294)