Accession | ARO:3000153 |
Definition | A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. |
Drug Class | aminoglycoside antibiotic |
Resistance Mechanism | antibiotic inactivation |
Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + phosphorylation of antibiotic conferring resistance + antibiotic molecule |
Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + aminoglycoside phosphotransferase (APH) |
Sub-Term(s) | 2 ontology terms | Show |
Publications | Fong DH, et al. 2010. J Biol Chem 285(13): 9545-9555. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. (PMID 20089863) Thompson PR, et al. 1998. J Biol Chem 273(24): 14788-14795. Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. (PMID 9614079) |
Curator | Description | Most Recent Edit |
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