APH(9) [AMR Gene Family]

Accession ARO:3000153
DefinitionA category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
2 ontology terms | Show

Fong DH, et al. 2010. J Biol Chem 285(13): 9545-9555. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. (PMID 20089863)

Thompson PR, et al. 1998. J Biol Chem 273(24): 14788-14795. Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. (PMID 9614079)