APH(2'') [AMR Gene Family]

Accession ARO:3000128
DefinitionA category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
6 ontology terms | Show