APH(3') [AMR Gene Family]

Accession ARO:3000126
DefinitionA category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
10 ontology terms | Show

Hon WC, et al. 1997. Cell 89(6): 887-895. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. (PMID 9200607)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)