APH(3') [AMR Gene Family]

Accession ARO:3000126
DefinitionPhosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3'
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic neomycin [Antibiotic]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ aminoglycoside phosphotransferase (APH)
+ confers_resistance_to_antibiotic G418 [Antibiotic]
18 ontology terms | Show

Hon WC, et al. 1997. Cell 89(6): 887-895. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. (PMID 9200607)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)