| Accession | ARO:3000126 |
| Definition | A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + phosphorylation of antibiotic conferring resistance + antibiotic molecule |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + aminoglycoside phosphotransferase (APH) |
| Sub-Term(s) | 10 ontology terms | Show + APH(3')-VIIIa + APH(3')-VIIIb + APH(3')-IXa + APH(3')-I + APH(3')-II + APH(3')-III + APH(3')-IV + APH(3')-V + APH(3')-VI + APH(3')-VII |
| Publications | Hon WC, et al. 1997. Cell 89(6): 887-895. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. (PMID 9200607) Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262) |