| Accession | ARO:3000491 |
| CARD Short Name | acrD |
| Definition | AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Escherichia colig+p+wgs, Klebsiella oxytocap, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Bacteroides thetaiotaomicronwgs, Citrobacter amalonaticuswgs, Citrobacter freundiig+wgs, Citrobacter koseriwgs, Citrobacter portucalensisg, Citrobacter werkmaniiwgs, Cronobacter sakazakiiwgs, Enterobacter asburiaewgs, Enterobacter hormaecheig+wgs, Erysipelatoclostridium ramosumwgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Escherichia marmotaeg+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella oxytocap, Klebsiella pneumoniaeg+wgs, Klebsiella quasipneumoniaewgs, Neisseria gonorrhoeaewgs, Proteus vulgariswgs, Pseudomonas aeruginosawgs, Salmonella entericag+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Staphylococcus aureuswgs, Staphylococcus capitiswgs, Vibrio choleraewgs |
| Classification | 6 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + antibiotic molecule |
| Parent Term(s) | 2 ontology terms | Show + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Rosenberg EY, et al. 2000. J Bacteriol 182(6): 1754-1756. AcrD of Escherichia coli is an aminoglycoside efflux pump. (PMID 10692383) |
Prevalence of acrD among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.07% | 0% |
| Bacteroides thetaiotaomicron | 0% | 0% | 1.08% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 2.08% | 0% |
| Citrobacter freundii | 19.64% | 0% | 24.76% | 0% |
| Citrobacter koseri | 0% | 0% | 2.08% | 0% |
| Citrobacter portucalensis | 4% | 0% | 0% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Cronobacter sakazakii | 0% | 0% | 0.24% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.44% | 0% |
| Enterobacter hormaechei | 0.43% | 0% | 0.6% | 0% |
| Erysipelatoclostridium ramosum | 0% | 0% | 1.28% | 0% |
| Escherichia albertii | 100% | 0% | 94.62% | 0% |
| Escherichia coli | 64.45% | 0.09% | 68.31% | 0% |
| Escherichia fergusonii | 0% | 0% | 2.82% | 0% |
| Escherichia marmotae | 100% | 0% | 69.57% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.93% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.9% | 0% |
| Klebsiella oxytoca | 0% | 0.82% | 0% | 0% |
| Klebsiella pneumoniae | 0.07% | 0% | 0.33% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.16% | 0% |
| Neisseria gonorrhoeae | 0% | 0% | 0.12% | 0% |
| Proteus vulgaris | 0% | 0% | 6.67% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.06% | 0% |
| Salmonella enterica | 0.36% | 0% | 1.24% | 0% |
| Shigella boydii | 100% | 0% | 98.9% | 0% |
| Shigella dysenteriae | 100% | 0% | 100% | 0% |
| Shigella flexneri | 100% | 0% | 82.14% | 0% |
| Shigella sonnei | 100% | 0% | 96.07% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.02% | 0% |
| Staphylococcus capitis | 0% | 0% | 0.65% | 0% |
| Vibrio cholerae | 0% | 0% | 0.14% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1900