neomycin [Antibiotic]

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Accession ARO:0000005
Synonym(s)Fradiomycin Fradiomycinum framycetin Framycetinum Mycifradin Neomas neomycin B Soframycin
DefinitionNeomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
SMILESN/A
PubChem8378
ChEBI7507
ChEMBLCHEMBL3989751
CAS1404-04-2
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
30 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin confers_resistance_to_antibiotic
+ aphA15 confers_resistance_to_antibiotic
+ AAC(3)-VIIIa confers_resistance_to_antibiotic
+ AAC(3)-IXa confers_resistance_to_antibiotic
+ kamB confers_resistance_to_antibiotic
+ PmpM confers_resistance_to_antibiotic
+ AAC(6')-31 confers_resistance_to_antibiotic
+ npmA confers_resistance_to_antibiotic
+ AAC(3)-IIIa confers_resistance_to_antibiotic
+ AAC(3)-IIIb confers_resistance_to_antibiotic
+ APH(3')-Ib confers_resistance_to_antibiotic
+ APH(3')-Ia confers_resistance_to_antibiotic
+ APH(3')-IIc confers_resistance_to_antibiotic
+ APH(3')-IIb confers_resistance_to_antibiotic
+ APH(3')-IIa confers_resistance_to_antibiotic
+ APH(3')-IIIa confers_resistance_to_antibiotic
+ APH(3')-IVa confers_resistance_to_antibiotic
+ APH(3')-Va confers_resistance_to_antibiotic
+ APH(3')-Vb confers_resistance_to_antibiotic
+ APH(3')-Vc confers_resistance_to_antibiotic
+ APH(3')-VIa confers_resistance_to_antibiotic
+ APH(3')-VIb confers_resistance_to_antibiotic
+ APH(3')-VIIa confers_resistance_to_antibiotic
+ AcrAD-TolC confers_resistance_to_antibiotic
+ acrD confers_resistance_to_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)
Curator Acknowledgements
Curator Description Most Recent Edit