Accession ARO:3004082
CARD Short NameAcrAD-TolC
DefinitionAcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_antibiotic amikacin [Antibiotic]
+ confers_resistance_to_antibiotic gentamicin [Antibiotic]
+ confers_resistance_to_antibiotic neomycin [Antibiotic]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
2 ontology terms | Show
+ baeSR regulates
+ cpxAR regulates

Rosenberg EY, et al. 2000. J Bacteriol 182(6): 1754-1756. AcrD of Escherichia coli is an aminoglycoside efflux pump. (PMID 10692383)

Poole K. 2004. Clin Microbiol Infect 10(1): 12-26. Efflux-mediated multiresistance in Gram-negative bacteria. (PMID 14706082)


Prevalence of AcrAD-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data

Detection Models

Model Name: AcrAD-TolC

Model Description: The AcrAD-TolC efflux pump system in E. coli confers resistance to amikacin, gentamicin, and tobramycin.

cpxAbaeRacrDTolCbaeSEscherichia coli acrAEscherichia coli CpxR