Accession ARO:3000531
DefinitionBaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification16 ontology terms | Show
Parent Term(s)4 ontology terms | Show
2 ontology terms | Show
+ baeR part_of
+ baeS part_of

Baranova N and Nikaido H. 2002. J Bacteriol 184(15): 4168-4176. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. (PMID 12107134)

Nishino K, et al. 2005. J Bacteriol 187(5): 1763-1772. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. (PMID 15716448)