aminocoumarin antibiotic [Drug Class]

Accession ARO:3000103
DefinitionAminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
19 ontology terms | Show
+ novobiocin [Antibiotic]
+ clorobiocin [Antibiotic]
+ coumermycin A1 [Antibiotic]
+ Vanillobiocin
+ Isovanillobiocin
+ Declovanillobiocin
+ antibiotic sensitive DNA topoisomerase subunit gyrB targeted_by
+ aminocoumarin sensitive parE targeted_by
+ aminocoumarin sensitive gyrB targeted_by
+ aminocoumarin sensitive parY targeted_by
+ aminocoumarin resistant gyrB [AMR Gene Family] confers_resistance_to_drug_class
+ aminocoumarin resistant parE [AMR Gene Family] confers_resistance_to_drug_class
+ determinant of aminocoumarin resistance confers_resistance_to_drug_class
+ aminocoumarin resistant parY [AMR Gene Family] confers_resistance_to_drug_class
+ aminocoumarin resistant alaS [AMR Gene Family] confers_resistance_to_drug_class
+ aminocoumarin resistant cysB [AMR Gene Family] confers_resistance_to_drug_class
+ aminocoumarin self resistant parY [AMR Gene Family] confers_resistance_to_drug_class
+ small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
Publications

Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802)