aminocoumarin resistant parE [AMR Gene Family]

Accession ARO:3000457
DefinitionParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance.
Drug Classaminocoumarin antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show

Fujimoto-Nakamura M, et al. 2005. Antimicrob Agents Chemother 49(9): 3810-3815. Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus. (PMID 16127057)