aminocoumarin sensitive parE

Accession ARO:3000023
DefinitionSubunit of the topoisomerase IV sensitive to aminocoumarins.
Drug Classaminocoumarin antibiotic
Classification4 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ targeted_by aminocoumarin antibiotic [Drug Class]
+ targeted_by_antibiotic novobiocin [Antibiotic]
+ targeted_by_antibiotic coumermycin A1 [Antibiotic]
+ targeted_by_antibiotic clorobiocin [Antibiotic]
+ antibiotic sensitive DNA topoisomerase subunit parE
1 ontology terms | Show
+ aminocoumarin resistant parE [AMR Gene Family] derives_from

Fujimoto-Nakamura M, et al. 2005. Antimicrob Agents Chemother 49(9): 3810-3815. Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus. (PMID 16127057)

Schmutz E, et al. 2003. Antimicrob Agents Chemother 47(3): 869-877. Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (PMID 12604514)