clorobiocin [Antibiotic]

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Accession ARO:3000132
DefinitionClorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.
Drug Classaminocoumarin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
9 ontology terms | Show

Fairweather NF, et al. 1980. J Bacteriol 142(1): 153-161. Inhibition of deoxyribonucleic acid gyrase: effects on nucleic acid synthesis and cell division in Escherichia coli K-12. (PMID 6154685)

Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802)

Lafitte D, et al. 2002. Biochemistry 41(23): 7217-7223. DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. (PMID 12044152)