antibiotic sensitive DNA topoisomerase subunit gyrB

Accession ARO:3000734
Synonym(s)gyrase B gyrase beta subunit gyrase subunit B
DefinitionDNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling.
Drug Classaminocoumarin antibiotic
Classification3 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ targeted_by aminocoumarin antibiotic [Drug Class]
+ targeted_by_antibiotic novobiocin [Antibiotic]
+ targeted_by_antibiotic coumermycin A1 [Antibiotic]
+ targeted_by_antibiotic clorobiocin [Antibiotic]
+ antibiotic sensitive topoisomerase subunit
3 ontology terms | Show

Reece RJ and Maxwell A. 1991. Crit Rev Biochem Mol Biol 26(3-4): 335-375. DNA gyrase: structure and function. (PMID 1657531)

Drlica K and Zhao X. 1997. Microbiol Mol Biol Rev 61(3): 377-392. DNA gyrase, topoisomerase IV, and the 4-quinolones. (PMID 9293187)