Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000111 |
Synonym(s) | cathomycin streptonivicin |
Definition | Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling. |
SMILES | CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C |
PubChem | 54675769 |
ChEMBL | CHEMBL36506 |
ChEBI | 28368 |
CAS | 303-81-1 |
Drug Class | aminocoumarin antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + aminocoumarin antibiotic [Drug Class] |
Sub-Term(s) | 18 ontology terms | Show + antibiotic sensitive DNA topoisomerase subunit gyrB targeted_by_antibiotic + aminocoumarin sensitive parE targeted_by_antibiotic + aminocoumarin sensitive gyrB targeted_by_antibiotic + aminocoumarin sensitive parY targeted_by_antibiotic + MdtABC-TolC confers_resistance_to_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + novA confers_resistance_to_antibiotic + Bartonella bacilliformis gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Escherichia coli gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Staphylococcus aureus gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Staphylococcus aureus parE conferring resistance to aminocoumarin confers_resistance_to_antibiotic + Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin confers_resistance_to_antibiotic + MexCD-OprJ confers_resistance_to_antibiotic + MuxABC-OpmB confers_resistance_to_antibiotic + aminocoumarin resistant cysB [AMR Gene Family] confers_resistance_to_antibiotic + Aminocoumarin resistant alaS [AMR Gene Family] confers_resistance_to_antibiotic + abeS confers_resistance_to_antibiotic + LptD confers_resistance_to_antibiotic |
Publications | Kominek LA. 1972. Antimicrob Agents Chemother 1(2): 123-134. Biosynthesis of novobiocin by Streptomyces niveus. (PMID 4680802) Steffensky M, et al. 2000. Antimicrob Agents Chemother 44(5): 1214-1222. Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (PMID 10770754) Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802) |
Curator | Description | Most Recent Edit |
---|