novobiocin [Antibiotic]

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Accession ARO:3000111
Synonym(s)streptonivicin cathomycin
DefinitionNovobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.
Drug Classaminocoumarin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
18 ontology terms | Show
+ antibiotic sensitive DNA topoisomerase subunit gyrB targeted_by_antibiotic
+ aminocoumarin sensitive parE targeted_by_antibiotic
+ aminocoumarin sensitive gyrB targeted_by_antibiotic
+ aminocoumarin sensitive parY targeted_by_antibiotic
+ MdtABC-TolC confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ novA confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Escherichia coli gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ MexCD-OprJ confers_resistance_to_antibiotic
+ MuxABC-OpmB confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ aminocoumarin resistant cysB [AMR Gene Family] confers_resistance_to_antibiotic
+ aminocoumarin resistant alaS [AMR Gene Family] confers_resistance_to_antibiotic
+ abeS confers_resistance_to_antibiotic
Publications

Kominek LA. 1972. Antimicrob Agents Chemother 1(2): 123-134. Biosynthesis of novobiocin by Streptomyces niveus. (PMID 4680802)

Steffensky M, et al. 2000. Antimicrob Agents Chemother 44(5): 1214-1222. Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (PMID 10770754)

Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802)