novobiocin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000111
Synonym(s)cathomycin streptonivicin
DefinitionNovobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.
SMILESCO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C
PubChem54675769
ChEMBLCHEMBL36506
ChEBI28368
CAS303-81-1
Drug Classaminocoumarin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
18 ontology terms | Show
+ antibiotic sensitive DNA topoisomerase subunit gyrB targeted_by_antibiotic
+ aminocoumarin sensitive parE targeted_by_antibiotic
+ aminocoumarin sensitive gyrB targeted_by_antibiotic
+ aminocoumarin sensitive parY targeted_by_antibiotic
+ MdtABC-TolC confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ novA confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Escherichia coli gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrB conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin confers_resistance_to_antibiotic
+ MexCD-OprJ confers_resistance_to_antibiotic
+ MuxABC-OpmB confers_resistance_to_antibiotic
+ aminocoumarin resistant cysB [AMR Gene Family] confers_resistance_to_antibiotic
+ Aminocoumarin resistant alaS [AMR Gene Family] confers_resistance_to_antibiotic
+ abeS confers_resistance_to_antibiotic
+ LptD confers_resistance_to_antibiotic
Publications

Kominek LA. 1972. Antimicrob Agents Chemother 1(2): 123-134. Biosynthesis of novobiocin by Streptomyces niveus. (PMID 4680802)

Steffensky M, et al. 2000. Antimicrob Agents Chemother 44(5): 1214-1222. Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (PMID 10770754)

Maxwell A. 1993. Mol Microbiol 9(4): 681-686. The interaction between coumarin drugs and DNA gyrase. (PMID 8231802)

Curator Acknowledgements
Curator Description Most Recent Edit