MuxABC-OpmB

Accession ARO:3004076
DefinitionMuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, triclosan, glycylcycline, antibacterial free fatty acids, fluoroquinolone antibiotic, monobactam, diaminopyrimidine antibiotic, penam, aminocoumarin antibiotic, carbapenem, macrolide antibiotic, acridine dye, aminoglycoside antibiotic, phenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification22 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic novobiocin [Antibiotic]
+ confers_resistance_to_antibiotic aztreonam [Antibiotic]
+ confers_resistance_to_antibiotic kitasamycin [Antibiotic]
+ confers_resistance_to_antibiotic rokitamycin [Antibiotic]
Sub-Term(s)
4 ontology terms | Show
+ OpmB part_of
+ MuxA part_of
+ MuxB part_of
+ MuxC part_of
Publications

Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238)

Resistomes

Prevalence of MuxABC-OpmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MuxABC-OpmB

Model Description: MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin.

OpmBMuxAMuxBMuxC