Accession | ARO:3004076 |
CARD Short Name | MuxABC-OpmB |
Definition | MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin. |
AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
Drug Class | tetracycline antibiotic, macrolide antibiotic, aminocoumarin antibiotic, monobactam |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + tetracycline antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + macrolide antibiotic [Drug Class] + aminocoumarin antibiotic [Drug Class] + monobactam [Drug Class] |
Parent Term(s) | 7 ontology terms | Show + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic novobiocin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic kitasamycin [Antibiotic] + confers_resistance_to_antibiotic rokitamycin [Antibiotic] |
Sub-Term(s) | 4 ontology terms | Show |
Publications | Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238) |
Prevalence of MuxABC-OpmB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
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No prevalence data | ||||