MuxC

Accession ARO:3004075
Synonym(s)PA2526
DefinitionMuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, macrolide antibiotic, aminocoumarin antibiotic, triclosan, monobactam, antibacterial free fatty acids, glycylcycline, fluoroquinolone antibiotic, carbapenem, acridine dye, aminoglycoside antibiotic, penam, diaminopyrimidine antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification29 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238)

Resistomes

Prevalence of MuxC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Citrobacter freundii0%0%0%
Klebsiella oxytoca0%0%0%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|AAG05914|-|MuxC [Pseudomonas aeruginosa PAO1]
MSLSTPFIRRPVATTLLTLALLLAGTLSFGLLPVAPLPNVDFPAIVVSASLPGASPETMASSVATPLERSLGRIAGISEMTSSSSLGSTT
VVLVFDLEKDIDGAAREVQAAINGAMSLLPSGMPNNPSYRKANPSDMPIMVLTLTSETQSRGEMYDLASTVLAPKLSQVQGVGQVSIGGS
SLPAVRVDLNPDAMSQYGLSLDSVRTAIAAANSNGPKGAVEKDDKHWQVDANDQLRKAREYEPLVIHYNADNGAAVRLGDVAKVSDSVED
VRNAGFSDDLPAVLLIVTRQPGANIIEATDAIHAQLPVLQELLGPQVKLNVMDDRSPSIRASLEEAELTLLISVALVILVVFLFLRNGRA
TLIPSLAVPVSLIGTFAVMYLCDFSLNNLSLMALIIATGFVVDDAIVVVENIARRIEEGDPPIQAAITGARQVGFTVLSMTLSLVAVFIP
LLLMGGLTGRLFREFAVTLSAAILVSLVVSLTLTPMLCARLLRPLKRPEGASLARRSDRFFAAFMLRYRASLGWALEHSRLMVVIMLACI
AMNLWLFVVVPKGFLPQQDSGRLRGYAVADQSISFQSLSAKMGEYRKILSSDPAVENVVGFIGGGRWQSSNTGSFFVTLKPIGERDPVEK
VLTRLRERIAKVPGAALYLNAGQDVRLGGRDSNAQYEFTLRSDDLTLLREWAPKVEAAMRKLPQLVDVNSDSQDKGVQTRLVIDRDRAAT
LGINVEMVDAVLNDSFGQRQVSTIFNPLNQYRVVMEVDQQYQQSPEILRQVQVIGNDGQRVPLSAFSHYEPSRAPLEVNHQGQFAATTLS
FNLAPGAQIGPTREAIMQALEPLHIPVDVQTSFEGNAGAVQDTQNQMPWLILLALLAVYIVLGILYESYVHPLTILSTLPSAGVGALLAL
ILCRSELSLIALIGIILLIGIVKKNAIMMIDFALEAERNHGLSPREAILEACMMRFRPIMMTTLAALLGALPLIFGIGGDAALRRPLGIT
IVGGLIGSQLLTLYTTPVVYLYLDRLRHWVNQKRGVRTDGALETPL


>gb|AE004091.2|-|2847776-2850886|MuxC [Pseudomonas aeruginosa PAO1]
ATGAGTCTGTCCACGCCCTTCATCCGCCGCCCGGTCGCCACCACGCTGCTGACCCTGGCGTTGCTGCTGGCCGGCACCCTGTCGTTCGGC
CTGCTGCCGGTGGCGCCGCTGCCCAACGTCGATTTTCCGGCCATCGTGGTCAGCGCCAGCCTGCCGGGCGCCAGCCCGGAAACCATGGCC
TCGTCGGTGGCCACGCCGCTGGAGCGCTCGCTGGGACGGATCGCCGGGATCAGCGAGATGACCTCCAGCAGTTCGCTGGGCTCGACCACC
GTGGTGCTCGTGTTCGACCTGGAGAAGGACATCGACGGCGCCGCCCGCGAGGTGCAGGCGGCGATCAACGGCGCGATGAGCCTGCTGCCC
AGCGGTATGCCGAACAATCCCAGCTACCGCAAGGCCAACCCCTCGGACATGCCGATCATGGTCCTCACCCTGACCTCGGAGACCCAGAGT
CGCGGCGAGATGTACGACCTCGCCTCGACCGTGCTGGCGCCCAAGCTGTCGCAGGTGCAGGGGGTAGGGCAGGTGAGCATCGGCGGCAGC
TCGCTGCCGGCGGTGCGGGTCGACCTCAACCCGGATGCCATGAGCCAGTACGGGCTGTCCCTGGACAGCGTGCGCACGGCCATCGCCGCG
GCCAACAGCAACGGCCCCAAGGGCGCCGTCGAGAAGGACGACAAGCACTGGCAGGTGGACGCCAACGACCAGTTGCGCAAGGCCCGCGAG
TACGAGCCGCTGGTGATCCACTACAACGCCGACAACGGCGCCGCGGTGCGCCTCGGCGACGTGGCCAAGGTCAGCGACTCGGTGGAGGAC
GTGCGCAACGCCGGCTTTTCCGACGACCTGCCGGCTGTGCTGCTAATCGTCACCCGCCAGCCCGGCGCCAACATCATCGAGGCCACCGAC
GCCATCCACGCGCAACTGCCGGTGTTGCAGGAACTGCTCGGGCCGCAGGTCAAGCTGAACGTGATGGACGATCGCAGCCCGTCGATCCGT
GCGTCGCTGGAAGAGGCCGAGCTGACCCTGCTGATCTCGGTGGCGCTGGTGATCCTGGTGGTCTTCCTGTTCCTGCGCAACGGCCGCGCC
ACGCTGATCCCCAGCCTGGCGGTGCCGGTCTCGCTGATCGGCACCTTCGCGGTCATGTACCTGTGCGACTTCAGCCTGAACAACCTGTCG
CTGATGGCGCTGATCATCGCCACCGGCTTCGTGGTGGATGACGCCATAGTGGTGGTGGAGAACATCGCCCGACGCATCGAGGAGGGCGAT
CCGCCGATCCAGGCGGCGATCACCGGCGCCCGCCAGGTCGGTTTCACCGTGCTGTCGATGACGCTCTCGCTGGTCGCGGTGTTCATCCCG
CTGCTGCTCATGGGTGGCCTCACCGGACGGCTGTTCCGCGAGTTCGCGGTGACTCTCTCGGCGGCGATCCTGGTGTCCCTGGTGGTATCC
CTGACCCTCACGCCGATGCTCTGCGCGCGTCTGCTGCGTCCGCTGAAACGGCCCGAAGGCGCTTCCCTGGCGCGGCGCAGCGATCGCTTC
TTCGCCGCCTTCATGCTGCGCTACCGCGCCAGCCTGGGCTGGGCGCTGGAGCACTCGCGGCTGATGGTGGTGATCATGCTGGCCTGCATC
GCCATGAACCTCTGGTTGTTCGTGGTGGTGCCCAAGGGCTTCCTCCCGCAGCAGGACTCCGGGCGCCTGCGCGGCTACGCGGTGGCCGAC
CAGAGCATCTCGTTCCAGTCCCTGAGCGCGAAGATGGGCGAGTACCGCAAGATCCTCTCTTCCGATCCGGCGGTGGAAAACGTGGTCGGC
TTCATCGGTGGCGGCCGTTGGCAGTCGAGCAACACCGGTTCGTTCTTCGTCACTCTCAAGCCGATCGGCGAGCGCGACCCGGTGGAGAAG
GTCCTCACCCGGCTGCGCGAGCGGATCGCCAAGGTGCCCGGCGCGGCGCTCTATCTCAACGCCGGCCAGGACGTGCGCCTGGGCGGCCGC
GACAGCAACGCGCAGTACGAATTCACCCTGCGCAGCGACGACCTGACCCTGCTCCGCGAATGGGCGCCGAAGGTCGAGGCGGCGATGCGC
AAGCTGCCGCAGCTGGTGGACGTCAACAGCGACTCCCAGGACAAGGGCGTGCAGACCCGCCTGGTGATCGACCGCGACCGCGCGGCGACC
CTGGGGATCAACGTGGAAATGGTCGACGCGGTGCTCAACGACTCTTTCGGCCAGCGCCAGGTGTCGACCATCTTCAACCCGCTGAACCAG
TACCGGGTGGTGATGGAGGTCGACCAGCAGTACCAGCAGAGCCCGGAGATCCTCCGCCAGGTCCAGGTGATCGGCAACGACGGCCAGCGC
GTGCCGCTGTCCGCGTTCAGCCACTACGAACCGAGCCGGGCACCGCTGGAGGTCAACCACCAGGGCCAGTTCGCCGCCACCACGCTGTCC
TTCAACCTGGCACCGGGCGCGCAGATCGGCCCGACCCGCGAGGCCATCATGCAGGCCCTGGAGCCGCTGCACATCCCGGTGGACGTGCAG
ACCAGCTTCGAGGGCAACGCCGGCGCGGTGCAGGACACGCAGAACCAGATGCCCTGGCTGATCCTCCTGGCGCTGCTGGCGGTGTACATC
GTCCTCGGCATCCTCTACGAGAGCTACGTGCACCCGCTGACCATCCTCTCGACCCTGCCTTCGGCCGGGGTCGGCGCGCTGCTCGCGCTG
ATCCTCTGCCGCAGCGAGCTGAGCCTGATCGCGCTGATCGGCATCATCCTGCTGATCGGCATCGTCAAGAAGAACGCGATCATGATGATC
GACTTCGCCCTGGAGGCCGAGCGCAACCACGGCCTGAGCCCGCGCGAGGCGATCCTCGAGGCCTGCATGATGCGCTTCCGGCCGATCATG
ATGACCACCCTGGCCGCCTTGCTCGGCGCCTTGCCGCTGATCTTCGGCATCGGCGGCGACGCCGCGCTGCGCCGGCCGCTGGGCATCACC
ATCGTCGGCGGGCTGATCGGCAGCCAGTTGCTGACCCTGTACACCACCCCGGTGGTCTACCTCTATCTCGACCGCCTGCGCCACTGGGTC
AACCAGAAACGCGGCGTACGCACGGACGGTGCGCTGGAGACACCCCTATGA