| Accession | ARO:0000004 |
| Definition | Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 21 ontology terms | Show + aztreonam [Antibiotic] + BAL30072 [Antibiotic] + carumonam [Antibiotic] + LYS228 [Antibiotic] + VCC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MdsABC confers_resistance_to_drug_class + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class + Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class + GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + VEB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + KPC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TEM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + BEL beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OXY beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + TLA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ACC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + MIR beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + OCH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + PDC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class + ampR transcriptional regulator with mutation conferring resistance to monobactam antibiotics [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804) Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791) Sykes RB and Bonner DP. 1985. Am J Med 78(2A): 2-10. Aztreonam: the first monobactam. (PMID 3871589) Gutmann L, et al. 1989. Antimicrob. Agents Chemother. 33(6):951-6 SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams. (PMID 02669628) |