KPC beta-lactamase [AMR Gene Family]

Accession ARO:3000059
DefinitionKlebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2.
Drug Classcarbapenem, cephalosporin, monobactam, penam
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ class A beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class monobactam [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
88 ontology terms | Show

Ke W, et al. 2007. Biochemistry 46(19): 5732-5740. Crystal structure of KPC-2: insights into carbapenemase activity in class A beta-lactamases. (PMID 17441734)

Stachyra T, et al. 2009. J Antimicrob Chemother 64(2): 326-329. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. (PMID 19493866)