| Accession | ARO:3002312 |
| Synonym(s) | KPC-1 |
| CARD Short Name | KPC-2 |
| Definition | KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. |
| AMR Gene Family | KPC beta-lactamase |
| Drug Class | penam, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniip, Alcaligenes faecaliswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiip+wgs, Proteus mirabilisg+p+wgs, Pseudomonas aeruginosag+p+wgs, Raoultella planticolap+wgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Staphylococcus aureuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniip, Alcaligenes faecaliswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Klebsiella aerogenesp+wgs, Klebsiella huaxiensisp, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiip+wgs, Proteus mirabilisg+p+wgs, Pseudomonas aeruginosag+p+wgs, Raoultella planticolap+wgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Staphylococcus aureuswgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + class A beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + KPC beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 13 ontology terms | Show + BLI-489 [Adjuvant] is_small_molecule_inhibitor + ANT3310 [Adjuvant] is_small_molecule_inhibitor + avibactam [Adjuvant] is_small_molecule_inhibitor + relebactam [Adjuvant] is_small_molecule_inhibitor + vaborbactam [Adjuvant] is_small_molecule_inhibitor + Xeruborbactam [Adjuvant] is_small_molecule_inhibitor + taniborbactam [Adjuvant] is_small_molecule_inhibitor + durlobactam [Adjuvant] is_small_molecule_inhibitor + nacubactam [Adjuvant] is_small_molecule_inhibitor + zidebactam [Adjuvant] is_small_molecule_inhibitor + ARX1796 [Adjuvant] is_small_molecule_inhibitor + ledaborbactam [Adjuvant] is_small_molecule_inhibitor + ledaborbactam etzadroxil [Adjuvant] is_small_molecule_inhibitor |
| Publications | Smith Moland E, et al. 2003. J Antimicrob Chemother 51(3): 711-714. Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates. (PMID 12615876) Villegas MV, et al. 2007. Antimicrob. Agents Chemother. 51(4):1553-5 First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. (PMID 17261621) |
Prevalence of KPC-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Aeromonas caviae | 2.27% | 3.9% | 3.76% | 0% |
| Aeromonas hydrophila | 0% | 10.39% | 3.23% | 0% |
| Aeromonas veronii | 0% | 3.08% | 0% | 0% |
| Alcaligenes faecalis | 0% | 0% | 2.94% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 1.82% | 0% |
| Citrobacter freundii | 0% | 9.54% | 6.77% | 0% |
| Citrobacter koseri | 0% | 15% | 9.91% | 0% |
| Citrobacter portucalensis | 0% | 13.24% | 9.91% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 9.09% | 0% | 0% |
| Enterobacter asburiae | 0% | 0.83% | 3.16% | 0% |
| Enterobacter chengduensis | 0% | 0% | 20% | 0% |
| Enterobacter cloacae | 0% | 2.23% | 5.11% | 0% |
| Enterobacter hormaechei | 0% | 1.42% | 3.84% | 0% |
| Enterobacter kobei | 0% | 2.07% | 4.8% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 4.68% | 0% |
| Escherichia coli | 0.02% | 0.4% | 0.4% | 0% |
| Klebsiella aerogenes | 0% | 11.96% | 4.24% | 0% |
| Klebsiella huaxiensis | 0% | 15.38% | 0% | 0% |
| Klebsiella michiganensis | 0% | 10.86% | 6.91% | 0% |
| Klebsiella oxytoca | 2.56% | 5.48% | 2.94% | 0% |
| Klebsiella pneumoniae | 0.65% | 5.68% | 12.41% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.06% | 4.61% | 0% |
| Morganella morganii | 0% | 12.5% | 4.29% | 0% |
| Proteus mirabilis | 0.92% | 13.75% | 1.65% | 0% |
| Pseudomonas aeruginosa | 1.07% | 9.94% | 0.53% | 0% |
| Raoultella planticola | 0% | 9.3% | 12.82% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.02% | 0% |
| Serratia marcescens | 0% | 5.81% | 8.39% | 0% |
| Shigella sonnei | 0% | 0% | 0.22% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550
