BLI-489 [Adjuvant]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3007141
DefinitionBLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases.
SMILESO=C([O-])C1=CS[C@@H]2/C(=C\c3cn4c(n3)COCC4)C(=O)N12.[Na+]
PubChem9972353
ChEMBLCHEMBL4297265
Classification5 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ is_small_molecule_inhibitor_of NDM-5
+ is_small_molecule_inhibitor_of OXA-23
+ is_small_molecule_inhibitor_of KPC-2
+ beta-lactam derived beta-lactamase inhibitor
Publications

Shi S, et al. 2022. J Antimicrob Chemother 77(5):1301-1305 Synergistic effect of the novel β-lactamase inhibitor BLI-489 combined with imipenem or meropenem against diverse carbapenemase-producing carbapenem-resistant Enterobacterales. (PMID 35165715)

Curator Acknowledgements
Curator Description Most Recent Edit