| Accession | ARO:3000467 |
| CARD Short Name | NDM-5 |
| Definition | New Delhi beta-lactamase NDM-5. |
| AMR Gene Family | NDM beta-lactamase |
| Drug Class | cephalosporin, cephamycin, carbapenem, penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip, Klebsiella aerogenesp, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisg+wgs, Salmonella entericap+wgs |
| Resistomes with Sequence Variants | Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip, Klebsiella aerogenesp, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisg+wgs, Salmonella entericap+wgs |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + antibiotic molecule + hydrolysis of antibiotic conferring resistance + beta-lactamase + beta-lactam antibiotic + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + cephem + class B (metallo-) beta-lactamase + cephalosporin [Drug Class] + cephamycin [Drug Class] + subclass B1 (metallo-) beta-lactamase + carbapenem [Drug Class] + penam [Drug Class] |
| Parent Term(s) | 4 ontology terms | Show + NDM beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic cefoxitin [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ertapenem [Antibiotic] |
| Sub-Term(s) | 1 ontology terms | Show + BLI-489 [Adjuvant] is_small_molecule_inhibitor |
| Publications | Hornsey M, et al. 2011. Antimicrob Agents Chemother 55(12): 5952-5954. A Novel Variant, NDM-5, of the New Delhi Metallo-beta-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom. (PMID 21930874) |
Prevalence of NDM-5 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0.31% | 1.35% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 1.47% | 1.8% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Enterobacter cloacae | 0% | 1.12% | 0.64% | 0% |
| Enterobacter hormaechei | 0% | 0.39% | 1.25% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 1.44% | 0% |
| Escherichia coli | 0.07% | 0.88% | 1.57% | 0.13% |
| Escherichia fergusonii | 0% | 0.36% | 0% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 0% | 0% |
| Klebsiella michiganensis | 0% | 1.14% | 1.06% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.3% | 1.06% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 7.24% | 0% |
| Proteus mirabilis | 1.83% | 0% | 0.17% | 0% |
| Salmonella enterica | 0% | 0.22% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500