| Accession | ARO:0000060 |
| Synonym(s) | Pentacef Tazicef ceftazidima caftazidime Ceptaz Fortaz ceftazidimum Ceftazidim Tazidime CAZ |
| Definition | Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. |
| Drug Class | cephalosporin |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + cephalosporin [Drug Class] |
| Sub-Term(s) | 52 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + CAM-1 confers_resistance_to_antibiotic + ACI-1 confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic + MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic + Burkholderia pseudomallei Omp38 confers_resistance_to_antibiotic + SHV-12 confers_resistance_to_antibiotic + CTX-M-15 confers_resistance_to_antibiotic + CTX-M-55 confers_resistance_to_antibiotic + CMY-42 confers_resistance_to_antibiotic + NDM-5 confers_resistance_to_antibiotic + OXA-2 confers_resistance_to_antibiotic + PDC-3 confers_resistance_to_antibiotic + PDC-5 confers_resistance_to_antibiotic + PDC-9 confers_resistance_to_antibiotic + PDC-10 confers_resistance_to_antibiotic + TMB-1 confers_resistance_to_antibiotic + TMB-2 confers_resistance_to_antibiotic + MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic + MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic + CTX-M-27 confers_resistance_to_antibiotic + CMY-2 confers_resistance_to_antibiotic + CTX-M-3 confers_resistance_to_antibiotic + SCO-1 confers_resistance_to_antibiotic + NDM-33 confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic + MAB confers_resistance_to_antibiotic + Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime confers_resistance_to_antibiotic + KPC-123 confers_resistance_to_antibiotic + VIM-63 confers_resistance_to_antibiotic + PAM-1 confers_resistance_to_antibiotic + PAM-2 confers_resistance_to_antibiotic + Yrc-1 confers_resistance_to_antibiotic + KPC-95 confers_resistance_to_antibiotic + KPC-94 confers_resistance_to_antibiotic + KPC-86 confers_resistance_to_antibiotic + Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam confers_resistance_to_antibiotic + Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam confers_resistance_to_antibiotic + Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + KPC-96 confers_resistance_to_antibiotic + SSA confers_resistance_to_antibiotic + EBR-5 confers_resistance_to_antibiotic + KPC-100 confers_resistance_to_antibiotic + KPC-98 confers_resistance_to_antibiotic + KPC-97 confers_resistance_to_antibiotic + KPC-99 confers_resistance_to_antibiotic + ceftazidime-cloxacillin [Antibiotic] has_part + ceftazidime-clavulanic acid [Antibiotic+Adjuvant] has_part + ceftazidime-tazobactam [Antibiotic+Adjuvant] has_part + ceftazidime-avibactam [Antibiotic+Adjuvant] has_part |
| Publications | Neu HC and Labthavikul P. 1982. Antimicrob Agents Chemother 21(1): 11-18. Antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against Pseudomonas aeruginosa. (PMID 6805421) |
