CAM-1

Accession ARO:3004559
CARD Short NameCAM-1
DefinitionCAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital.
AMR Gene FamilyCAM beta-lactamase
Drug Classpenam, cephalosporin, cephamycin, carbapenem
Resistance Mechanismantibiotic inactivation
Classification24 ontology terms | Show
Parent Term(s)9 ontology terms | Show
+ confers_resistance_to_antibiotic cefoxitin [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic meropenem [Antibiotic]
+ confers_resistance_to_antibiotic imipenem [Antibiotic]
+ confers_resistance_to_antibiotic doripenem [Antibiotic]
+ confers_resistance_to_antibiotic cefotaxime [Antibiotic]
+ confers_resistance_to_antibiotic ceftolozane [Antibiotic]
+ confers_resistance_to_antibiotic piperacillin-tazobactam [Antibiotic+Adjuvant]
+ CAM beta-lactamase [AMR Gene Family]
Publications

Boyd DA, et al. 2019. J. Antimicrob. Chemother. : Identification of a novel metallo-β-lactamase, CAM-1, in clinical Pseudomonas aeruginosa isolates from Canada. (PMID 30789204)

Resistomes

Prevalence of CAM-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AVX51087.1|+|CAM-1 [Pseudomonas aeruginosa]
MKSTAIILFLLVFSLGVFGQTGDALKISQLSGDFYIFTTYQTYKDAKVSANGMYVVTDEGVVLIDTPWDETQLQPLLNYIKEKHNKDVVM
SVSTHFHEDRTNGIEFLRTKGVKTYTTKKTDELSQKKGYERAEFLLEKDTEFKIGQYKFQTYYPGEGHAPDNIVVWFPNERILYGGCFIK
STEAEDIGNLSDANIDEWSNSIKNVQKKFKNPKFVIPGHDGWASTKSLKHTLKLIKKTRKK


>gb|MG430339.1|+|67104-67829|CAM-1 [Pseudomonas aeruginosa]
ATGAAATCAACTGCAATTATTTTATTTTTACTCGTTTTTTCGCTCGGCGTTTTCGGGCAAACGGGCGATGCGCTGAAAATCTCTCAACTG
TCGGGCGATTTTTATATTTTTACGACTTATCAAACCTATAAAGACGCAAAAGTTTCCGCCAACGGAATGTATGTCGTGACCGACGAAGGC
GTTGTTTTGATCGACACGCCGTGGGATGAAACTCAGCTTCAGCCGCTTCTCAATTACATCAAGGAAAAGCACAACAAGGATGTCGTGATG
AGCGTTTCGACGCATTTTCACGAAGACCGCACGAACGGCATCGAATTTTTGAGGACAAAAGGCGTGAAAACCTACACGACCAAGAAAACC
GACGAGCTTTCGCAGAAAAAAGGTTACGAACGCGCCGAATTTTTGCTCGAAAAAGACACGGAATTCAAGATCGGGCAATACAAATTTCAA
ACCTACTATCCCGGCGAAGGTCACGCGCCCGACAATATCGTGGTCTGGTTTCCGAACGAAAGAATTCTTTACGGCGGTTGTTTCATAAAA
AGCACCGAAGCCGAAGACATCGGGAATTTGTCCGATGCAAATATCGATGAATGGTCAAACTCGATCAAAAACGTGCAGAAAAAATTCAAG
AACCCGAAATTCGTAATTCCCGGTCACGACGGATGGGCAAGCACGAAATCACTCAAACACACATTAAAACTTATCAAGAAAACCCGTAAA
AAATAA