| Accession | ARO:3000568 |
| Definition | Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs. |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + beta-lactamase |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 50 ontology terms | Show + VIM beta-lactamase [AMR Gene Family] + IMP beta-lactamase [AMR Gene Family] + NDM beta-lactamase [AMR Gene Family] + IND beta-lactamase [AMR Gene Family] + subclass B1 Bacillus cereus Bc beta-lactamase [AMR Gene Family] + SPM beta-lactamase [AMR Gene Family] + CAM beta-lactamase [AMR Gene Family] + GIM beta-lactamase [AMR Gene Family] + SHW beta-lactamase [AMR Gene Family] + MUS beta-lactamase [AMR Gene Family] + TMB beta-lactamase [AMR Gene Family] + CfiA beta-lactamase [AMR Gene Family] + BlaB beta-lactamase [AMR Gene Family] + JOHN beta-lactamase [AMR Gene Family] + CGB beta-lactamase [AMR Gene Family] + EBR beta-lactamase [AMR Gene Family] + TUS beta-lactamase [AMR Gene Family] + SIM beta-lactamase [AMR Gene Family] + KHM beta-lactamase [AMR Gene Family] + DIM beta-lactamase [AMR Gene Family] + HMB beta-lactamase [AMR Gene Family] + subclass B1 PEDO beta-lactamase [AMR Gene Family] + subclass B1 Bacillus anthracis Bla beta-lactamase [AMR Gene Family] + Subclass B1 Vibrio cholerae varG beta-lactamase [AMR Gene Family] + VMB beta-lactamase [AMR Gene Family] + AFM beta-lactamase [AMR Gene Family] + ALI beta-lactamase [AMR Gene Family] + ANA beta-lactamase [AMR Gene Family] + ECV beta-lactamase [AMR Gene Family] + FIA beta-lactamase [AMR Gene Family] + GMB beta-lactamase [AMR Gene Family] + GRD23 beta-lactamase [AMR Gene Family] + MOC beta-lactamase [AMR Gene Family] + MYO beta-lactamase [AMR Gene Family] + MYX beta-lactamase [AMR Gene Family] + ORR beta-lactamase [AMR Gene Family] + PST beta-lactamase [AMR Gene Family] + SHN beta-lactamase [AMR Gene Family] + SPN79 beta-lactamase [AMR Gene Family] + SPS beta-lactamase [AMR Gene Family] + STA beta-lactamase [AMR Gene Family] + TTU beta-lactamase [AMR Gene Family] + ZOG beta-lactamase [AMR Gene Family] + SHD beta-lactamase [AMR Gene Family] + VAM beta-lactamase [AMR Gene Family] + subclass B1 Bacteroides xylanisolvens crx beta-lactamase [AMR Gene Family] + CIM beta-lactamase [AMR Gene Family] + CHM beta-lactamase [AMR Gene Family] + DYB beta-lactamase [AMR Gene Family] + BMHC beta-lactamase [AMR Gene Family] |
| Publications | Lienard BM, et al. 2008. Org Biomol Chem 6(13): 2282-2294. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (PMID 18563261) |
| Curator | Description | Most Recent Edit |
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