subclass B1 (metallo-) beta-lactamase

Accession ARO:3000568
DefinitionSubclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs.
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
24 ontology terms | Show
+ VIM beta-lactamase [AMR Gene Family]
+ IMP beta-lactamase [AMR Gene Family]
+ NDM beta-lactamase [AMR Gene Family]
+ IND beta-lactamase [AMR Gene Family]
+ Bc beta-lactamase [AMR Gene Family]
+ SPM beta-lactamase [AMR Gene Family]
+ CAM beta-lactamase [AMR Gene Family]
+ GIM beta-lactamase [AMR Gene Family]
+ SHW beta-lactamase [AMR Gene Family]
+ MUS beta-lactamase [AMR Gene Family]
+ TMB beta-lactamase [AMR Gene Family]
+ CcrA beta-lactamase [AMR Gene Family]
+ BlaB beta-lactamase [AMR Gene Family]
+ JOHN beta-lactamase [AMR Gene Family]
+ CGB beta-lactamase [AMR Gene Family]
+ EBR beta-lactamase [AMR Gene Family]
+ TUS beta-lactamase [AMR Gene Family]
+ SIM beta-lactamase [AMR Gene Family]
+ KHM beta-latamase [AMR Gene Family]
+ DIM beta-lactamase [AMR Gene Family]
+ HMB beta-lactamase [AMR Gene Family]
+ subclass B1 PEDO beta-lactamase [AMR Gene Family]
+ subclass B1 Bacillus anthracis Bla beta-lactamase [AMR Gene Family]
+ subclass B1 Vibrio cholerae varG beta-lactamase [AMR Gene Family]
Publications

Lienard BM, et al. 2008. Org Biomol Chem 6(13): 2282-2294. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (PMID 18563261)