| Accession | ARO:3000021 |
| Definition | The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. |
| Drug Class | carbapenem, penam, cephalosporin, cephamycin, penem |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + antibiotic molecule + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + beta-lactamase + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + class B (metallo-) beta-lactamase + cephem |
| Parent Term(s) | 6 ontology terms | Show + subclass B1 (metallo-) beta-lactamase + confers_resistance_to_drug_class carbapenem [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class cephamycin [Drug Class] + confers_resistance_to_drug_class penem [Drug Class] |
| Sub-Term(s) | 73 ontology terms | Show + VIM-1 + VIM-2 + VIM-3 + VIM-4 + VIM-5 + VIM-6 + VIM-7 + VIM-8 + VIM-9 + VIM-10 + VIM-11 + VIM-12 + VIM-13 + VIM-14 + VIM-15 + VIM-16 + VIM-17 + VIM-18 + VIM-19 + VIM-20 + VIM-21 + VIM-22 + VIM-23 + VIM-24 + VIM-25 + VIM-26 + VIM-27 + VIM-28 + VIM-29 + VIM-30 + VIM-31 + VIM-32 + VIM-33 + VIM-34 + VIM-35 + VIM-36 + VIM-37 + VIM-38 + VIM-39 + VIM-40 + VIM-41 + VIM-42 + VIM-43 + VIM-44 + VIM-45 + VIM-46 + VIM-47 + VIM-48 + VIM-49 + VIM-50 + VIM-51 + VIM-52 + VIM-53 + VIM-54 + VIM-55 + VIM-56 + VIM-57 + VIM-58 + VIM-59 + VIM-60 + VIM-61 + VIM-62 + VIM-63 + VIM-64 + VIM-65 + VIM-66 + VIM-67 + VIM-68 + VIM-69 + VIM-70 + VIM-71 + VIM-72 + VIM-73 |
| Publications | Garcia-Saez I, et al. 2007. J Mol Biol 375(3): 604-611. The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form. (PMID 18061205) Oelschlaeger P, et al. 2010. J Med Chem 53(8): 3013-3027. Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?. (PMID 20121112) Docquier JD, et al. 2003. J Antimicrob Chemother 51(2): 257-266. On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. (PMID 12562689) |