JOHN beta-lactamase [AMR Gene Family]

Accession ARO:3004202
DefinitionJOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems.
Drug Classcephalosporin, carbapenem, penam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
1 ontology terms | Show

Naas T, et al. 2003. J Antimicrob Chemother 51(2): 267-273. Molecular and biochemical characterization of a carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae. (PMID 12562690)