IMP beta-lactamase [AMR Gene Family]

Accession ARO:3000020
DefinitionPlasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors.
Drug Classcarbapenem, penam, cephalosporin, cephamycin, penem
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ subclass B1 (metallo-) beta-lactamase
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ confers_resistance_to_drug_class penem [Drug Class]
90 ontology terms | Show

Osano E, et al. 1994. Antimicrob Agents Chemother 38(1): 71-78. Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. (PMID 8141584)

Oelschlaeger P, et al. 2010. J Med Chem 53(8): 3013-3027. Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?. (PMID 20121112)