| Accession | ARO:3002192 |
| CARD Short Name | IMP-1 |
| Definition | IMP-1 is a beta-lactamase found in Serratia marcescens. |
| AMR Gene Family | IMP beta-lactamase |
| Drug Class | cephamycin, cephalosporin, carbapenem, penem, penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Acinetobacter juniiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilawgs, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Enterobacter asburiaeg+p+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Escherichia coliwgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Providencia rettgerig, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas putidag+wgs, Pseudomonas stutzeriwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Acinetobacter juniiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilawgs, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Enterobacter asburiaeg+p+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Escherichia coliwgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Providencia rettgerig, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas putidag+wgs, Pseudomonas stutzeriwgs |
| Classification | 18 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + beta-lactamase + beta-lactam antibiotic + hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase + cephem + class B (metallo-) beta-lactamase + cephamycin [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + penem [Drug Class] + subclass B1 (metallo-) beta-lactamase + penam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + IMP beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 2 ontology terms | Show + taniborbactam [Adjuvant] is_small_molecule_inhibitor + ME1071 [Adjuvant] is_small_molecule_inhibitor |
| Publications | Osano E, et al. 1994. Antimicrob Agents Chemother 38(1): 71-78. Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. (PMID 8141584) |
Prevalence of IMP-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.03% | 0% |
| Acinetobacter junii | 0% | 0% | 2.99% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 0.57% | 0% |
| Acinetobacter pittii | 0% | 0% | 1.14% | 0% |
| Aeromonas caviae | 4.55% | 1.3% | 24.19% | 0% |
| Aeromonas hydrophila | 0% | 0% | 0.81% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% |
| Citrobacter freundii | 0% | 0% | 0.39% | 0% |
| Enterobacter asburiae | 3.23% | 0.83% | 2.77% | 0% |
| Enterobacter cloacae | 0% | 1.68% | 3.83% | 0% |
| Enterobacter hormaechei | 0.72% | 3.6% | 7.51% | 0% |
| Enterobacter kobei | 0% | 0.69% | 1.31% | 0% |
| Escherichia coli | 0% | 0% | 0.02% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.02% | 0.37% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.39% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Providencia rettgeri | 2.94% | 0% | 0% | 0% |
| Pseudomonas aeruginosa | 1.38% | 0.58% | 0.36% | 2.78% |
| Pseudomonas putida | 4.23% | 0% | 2.14% | 0% |
| Pseudomonas stutzeri | 0% | 0% | 6.87% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400