IMP-4

Accession ARO:3002195
CARD Short NameIMP-4
DefinitionIMP-4 is a beta-lactamase found in Acinetobacter baumannii.
AMR Gene FamilyIMP beta-lactamase
Drug Classpenem, cephamycin, cephalosporin, penam, carbapenem
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniip+wgs, Acinetobacter pittiiwgs, Aeromonas caviaep, Citrobacter amalonaticusp, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter asburiaep, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip, Escherichia colip+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap, Raoultella planticolap+wgs, Serratia marcescensp
Resistomes with Sequence VariantsAcinetobacter baumanniip+wgs, Acinetobacter pittiiwgs, Aeromonas caviaep, Citrobacter amalonaticusp, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter asburiaep, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip, Escherichia colip+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap, Raoultella planticolap+wgs, Serratia marcescensp
Classification18 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ IMP beta-lactamase [AMR Gene Family]
Sub-Term(s)
2 ontology terms | Show
+ avibactam [Adjuvant] is_small_molecule_inhibitor
+ ARX1796 [Adjuvant] is_small_molecule_inhibitor
Publications

Koh TH, et al. 2007. J Antimicrob Chemother 59(4): 627-632. IMP-4 and OXA beta-lactamases in Acinetobacter baumannii from Singapore. (PMID 17284537)

Resistomes

Prevalence of IMP-4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0.05%0.01%0%
Acinetobacter pittii0%0%0.28%0%
Aeromonas caviae0%1.3%0%0%
Citrobacter amalonaticus0%8.33%0%0%
Citrobacter freundii0%0.92%0.97%0%
Citrobacter portucalensis0%0%4.5%0%
Enterobacter asburiae0%0.28%0%0%
Enterobacter cloacae0%0%0.32%0%
Enterobacter hormaechei0%0.84%0.95%0%
Enterobacter kobei0%0.69%0%0%
Escherichia coli0%0.03%0.04%0%
Klebsiella aerogenes0%1.09%0.56%0%
Klebsiella michiganensis0%2.29%0.8%0%
Klebsiella pneumoniae0%0.17%0.21%0%
Klebsiella quasipneumoniae0%0.42%0.92%0%
Leclercia adecarboxylata0%4.76%0%0%
Raoultella planticola0%2.33%2.56%0%
Serratia marcescens0%1.29%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAK13078.1|+|IMP-4 [Acinetobacter baumannii]
MSKLSVFFIFLFCSIATAAEPLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVDAEAYLIDTPFTAKDTEKLVTWFVERGYKIKG
SISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFGGVNYWLVKNKIEVFYPGPGHTPDNLVVWLPERKILFGGCFIKP
YGLGNLGDANLEAWPKSAKLLISKYGKAKLVVPSHSEAGDASLLKLTLEQAVKGLNESKKPSKLSN


>gb|AF244145.1|+|1-741|IMP-4 [Acinetobacter baumannii]
ATGAGCAAGTTATCTGTATTCTTTATATTTTTGTTTTGTAGCATTGCTACCGCAGCAGAGCCTTTGCCAGATTTAAAAATTGAAAAACTT
GATGAAGGCGTTTATGTTCATACTTCGTTTGAAGAAGTTAACGGGTGGGGCGTTGTTCCTAAACATGGTTTGGTTGTTCTTGTAGATGCT
GAAGCTTATCTAATTGACACTCCATTTACGGCTAAAGATACTGAAAAGTTAGTCACTTGGTTTGTGGAACGTGGCTATAAAATAAAAGGC
AGTATTTCCTCTCATTTTCATAGTGACAGCACGGGCGGAATAGAGTGGCTTAATTCTCAATCCATCCCCACGTATGCGTCTGAATTAACT
AATGAGCTGCTTAAAAAAGACGGTAAGGTTCAAGCTAAAAATTCATTTGGCGGGGTTAACTATTGGCTAGTTAAAAATAAAATTGAAGTT
TTTTATCCAGGCCCAGGACACACTCCAGATAACCTAGTAGTTTGGCTGCCTGAAAGGAAAATATTATTCGGTGGTTGTTTTATTAAACCG
TACGGTCTAGGTAATTTGGGTGACGCAAATTTAGAAGCTTGGCCAAAGTCCGCTAAATTATTAATATCCAAATATGGTAAGGCAAAACTG
GTTGTTCCAAGTCACAGTGAAGCTGGAGACGCATCACTCTTGAAACTTACATTAGAGCAGGCGGTTAAAGGGTTAAACGAAAGTAAAAAA
CCATCAAAACTAAGCAACTAA