avibactam [Adjuvant]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000588
Synonym(s)NXL-104
DefinitionSerine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes.
SMILESNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
PubChem24944097
ChEBI85984
CAS1192500-31-4
ChEMBLCHEMBL1689063
AMR Gene FamilyOXA beta-lactamase, OXA-1-like beta-lactamase, class A Mycobacterium abscessus beta-lactamase, MOX beta-lactamase, ACT beta-lactamase, CMY beta-lactamase, KPC beta-lactamase, IMP beta-lactamase, CTX-M beta-lactamase, SHV beta-lactamase, TEM beta-lactamase
Drug Classpenicillin beta-lactam, cephalosporin, carbapenem, monobactam
Resistance Mechanismantibiotic inactivation
Classification56 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ mechanism of antibiotic resistance
+ determinant of antibiotic resistance
+ antibiotic molecule
+ antibiotic inactivation [Resistance Mechanism]
+ antibiotic inactivation enzyme
+ hydrolysis of antibiotic conferring resistance
+ beta-lactam antibiotic
+ hydrolysis of beta-lactam antibiotic by serine beta-lactamase
+ penicillin beta-lactam [Drug Class]
+ beta-lactamase
+ beta-lactamase resistant penicillin
+ hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase
+ class C beta-lactamase
+ resistance-modifying agents
+ penicillin with extended spectrum
+ inhibitor of antibiotic resistance mechanism
+ CMY-LAT-MOX beta-lactamase
+ class A beta-lactamase
+ class D beta-lactamase
+ class B (metallo-) beta-lactamase
+ oxacillin [Antibiotic]
+ cephalosporin [Drug Class]
+ third-generation cephalosporin
+ second-generation cephalosporin
+ first-generation cephalosporin
+ ampicillin [Antibiotic]
+ subclass B1 (metallo-) beta-lactamase
+ SHV-LEN beta-lactamase
+ CMY-MOX beta-lactamase
+ CMY-LAT beta-lactamase
+ beta-lactamase inhibitor
+ OXA beta-lactamase [AMR Gene Family]
+ carbapenem [Drug Class]
+ monobactam [Drug Class]
+ OXA-1-like beta-lactamase [AMR Gene Family]
+ class A Mycobacterium abscessus beta-lactamase [AMR Gene Family]
+ serine beta-lactamase inhibitor
+ ticarcillin [Antibiotic]
+ cefalotin [Antibiotic]
+ cefixime [Antibiotic]
+ MOX beta-lactamase [AMR Gene Family]
+ ACT beta-lactamase [AMR Gene Family]
+ CMY beta-lactamase [AMR Gene Family]
+ KPC beta-lactamase [AMR Gene Family]
+ IMP beta-lactamase [AMR Gene Family]
+ CTX-M beta-lactamase [AMR Gene Family]
+ SHV beta-lactamase [AMR Gene Family]
+ TEM beta-lactamase [AMR Gene Family]
+ piperacillin [Antibiotic]
+ ertapenem [Antibiotic]
+ amoxicillin [Antibiotic]
+ cefuroxime [Antibiotic]
+ ceftriaxone [Antibiotic]
+ ceftazidime [Antibiotic]
+ cefazolin [Antibiotic]
Parent Term(s)29 ontology terms | Show
+ is_small_molecule_inhibitor_of TEM-1
+ is_small_molecule_inhibitor_of TEM-3
+ is_small_molecule_inhibitor_of TEM-9
+ is_small_molecule_inhibitor_of TEM-10
+ is_small_molecule_inhibitor_of TEM-12
+ is_small_molecule_inhibitor_of TEM-26
+ is_small_molecule_inhibitor_of TEM-28
+ is_small_molecule_inhibitor_of TEM-71
+ is_small_molecule_inhibitor_of SHV-1
+ is_small_molecule_inhibitor_of SHV-2
+ is_small_molecule_inhibitor_of SHV-3
+ is_small_molecule_inhibitor_of SHV-4
+ is_small_molecule_inhibitor_of SHV-7
+ is_small_molecule_inhibitor_of SHV-18
+ is_small_molecule_inhibitor_of SHV-52
+ is_small_molecule_inhibitor_of OXA-1
+ is_small_molecule_inhibitor_of ACT-1
+ is_small_molecule_inhibitor_of CTX-M-15
+ is_small_molecule_inhibitor_of CTX-M-24
+ is_small_molecule_inhibitor_of CTX-M-27
+ is_small_molecule_inhibitor_of CTX-M-55
+ is_small_molecule_inhibitor_of CTX-M-65
+ is_small_molecule_inhibitor_of CMY-8
+ is_small_molecule_inhibitor_of MOX-1
+ is_small_molecule_inhibitor_of IMP-4
+ is_small_molecule_inhibitor_of KPC-2
+ is_small_molecule_inhibitor_of KPC-3
+ diazabicyclooctane
+ is_small_molecule_inhibitor_of MAB
Sub-Term(s)
3 ontology terms | Show
+ ceftazidime-avibactam [Antibiotic+Adjuvant] has_part
+ aztreonam-avibactam [Antibiotic+Adjuvant] has_part
+ ceftaroline-avibactam [Antibiotic+Adjuvant] has_part
Publications

Stachyra T, et al. 2010. Antimicrob Agents Chemother 54(12): 5132-5138. Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. (PMID 20921316)

Hidalgo JA, et al. 2016. Drug Des Devel Ther 10:2379-86 Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections. (PMID 27528799)

Torrens G, et al. 2016. Antimicrob. Agents Chemother. : Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms. (PMID 27480848)
Curator Acknowledgements
Curator Description Most Recent Edit