| Accession | ARO:3001917 |
| Synonym(s) | CTX-M-57 |
| CARD Short Name | CTX-M-55 |
| Definition | CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. |
| AMR Gene Family | CTX-M beta-lactamase |
| Drug Class | cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+wgs, Acinetobacter towneriwgs, Citrobacter freundiip, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexnerig+p+wgs, Shigella sonneip+wgs, Vibrio parahaemolyticuswgs, Vibrio vulnificusp+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Acinetobacter towneriwgs, Citrobacter freundiip, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexnerig+p+wgs, Shigella sonneip+wgs, Vibrio parahaemolyticuswgs, Vibrio vulnificusp+wgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + beta-lactam antibiotic + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + class A beta-lactamase + cephalosporin [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + CTX-M beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Kiratisin P, et al. 2007. Diagn Microbiol Infect Dis 58(3): 349-355. The emergence of a novel ceftazidime-resistant CTX-M extended-spectrum beta-lactamase, CTX-M-55, in both community-onset and hospital-acquired infections in Thailand. (PMID 17449211) |
Prevalence of CTX-M-55 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0% | 0.2% | 0% |
| Acinetobacter towneri | 0% | 0% | 3.85% | 0% |
| Citrobacter freundii | 0% | 0.31% | 0% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 1.28% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0.09% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0% | 0% |
| Escherichia albertii | 0% | 2.26% | 0% | 0% |
| Escherichia coli | 0.88% | 1.03% | 2.43% | 0.26% |
| Escherichia fergusonii | 0% | 0.36% | 3.26% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.26% | 0.6% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.26% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Proteus mirabilis | 0% | 0% | 0.17% | 0% |
| Salmonella enterica | 1.7% | 2.68% | 0.78% | 1.32% |
| Shigella boydii | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 1% | 2.01% | 1.55% | 0% |
| Shigella sonnei | 0% | 0.97% | 1.68% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
| Vibrio vulnificus | 0% | 5.56% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500